{"id":"W4392623357","doi":"10.1002/alz.13741","title":"Genetic associations with dementia‐related proteinopathy: Application of item response theory","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; National Heart, Lung, and Blood Institute; National Institute on Aging; European Research Council; Medical Research Council; Uniformed Services University of the Health Sciences; Österreichische Forschungsförderungsgesellschaft; National Institutes of Health; Austrian Science Fund; National Human Genome Research Institute; Russian Foundation for Basic Research; National Association for Colitis and Crohn's Disease; Texas Alzheimer's Research and Care Consortium; National Alzheimer's Coordinating Center; University of Toronto; Case Western Reserve University; Canadian Institutes of Health Research; University of Washington; European Commission; U.S. Department of Defense; Oesterreichische Nationalbank; Broad Institute; Alzheimer's Disease Neuroimaging Initiative; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Vanderbilt University; University of Pennsylvania; University of Miami; Alzheimer's Association","keywords":"Genetic architecture; Dementia; Endophenotype; Neuropathology; Dementia with Lewy bodies; Biology; Psychology; Phenotype; Neuroscience; Genetics; Medicine; Gene; Cognition; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04468795,0.001627706,0.001771365,0.00294768,0.0006924374,0.001386537,0.002173779,0.00147562,0.005504506],"category_scores_gemma":[0.0807271,0.0005489716,0.00477343,0.003650549,0.001701598,0.0009885526,0.002614811,0.001692011,0.0006754826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169316,"about_ca_system_score_gemma":0.001112388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002563918,"about_ca_topic_score_gemma":0.001455041,"domain_scores_codex":[0.9421685,0.05127421,0.0009874098,0.003495855,0.001633957,0.0004401124],"domain_scores_gemma":[0.9295111,0.05951059,0.002957568,0.006102088,0.001462246,0.000456533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002133007,0.0009984683,0.753776,0.0008582024,0.01037238,0.0004122458,0.001558015,0.1080334,0.001255713,0.01006195,0.002828493,0.1077122],"study_design_scores_gemma":[0.0004169785,0.002510496,0.2281498,0.00018322,0.001191186,0.0004918292,0.0007373562,0.707776,0.001232948,0.0543743,0.00274803,0.0001878268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5328932,0.000492606,0.457761,0.0008386125,0.0001158663,0.002518035,0.002805528,0.0009595979,0.001615428],"genre_scores_gemma":[0.9156399,0.00008571029,0.08029721,0.0001016682,0.00002691285,0.002242868,0.001172532,0.00005542133,0.0003778032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04468795,"threshold_uncertainty_score":0.2363353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015917742260483,"score_gpt":0.2906102985460587,"score_spread":0.2746925562855758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}