{"id":"W4392624771","doi":"10.1101/2024.03.08.584132","title":"Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; NMDA receptor; Schizophrenia (object-oriented programming); Glutamatergic; Postsynaptic density; Neuroscience; Postsynaptic potential; Cell biology; Receptor; Biology; Kinase; Psychology; Glutamate receptor; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001649858,0.0003750235,0.0004703207,0.0002978908,0.0001603656,0.0002632561,0.0003409675,0.0003454884,0.002116771],"category_scores_gemma":[0.0001179401,0.000193753,0.000257988,0.0001581719,0.0003228641,0.0001307222,0.0002817903,0.0007154929,0.0005787174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326325,"about_ca_system_score_gemma":0.000361334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438435,"about_ca_topic_score_gemma":0.002018255,"domain_scores_codex":[0.9998499,0.00001982407,0.0000218418,0.00002212832,0.00004306111,0.00004322796],"domain_scores_gemma":[0.9999052,0.000009520904,0.00002055666,0.00001305909,0.000007065861,0.0000446868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004111381,0.0001055768,0.0001607349,0.00003908571,0.00001499153,0.0001083931,0.00002028202,0.0001314505,0.9957612,0.000233073,0.0001214007,0.002892559],"study_design_scores_gemma":[0.0001328396,0.0009706157,0.004557153,0.00001675526,0.00004564953,0.0004762392,0.00006069525,0.001543329,0.9887053,0.0001728114,0.003308572,0.00001012182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931493,0.001023851,0.0029097,0.0002019023,0.00007349154,0.00003010759,0.0007074625,0.0002119391,0.001692196],"genre_scores_gemma":[0.9928764,0.0007522854,0.002049432,0.00007188562,0.00001069631,0.00003078381,0.0005932442,0.0000457074,0.003569577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002116771,"threshold_uncertainty_score":0.00708127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032673344593093,"score_gpt":0.2282623967453794,"score_spread":0.2179356632994484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}