{"id":"W4392624809","doi":"10.1111/imr.13316","title":"Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment","year":2024,"lang":"en","type":"review","venue":"Immunological Reviews","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre; Discovery Centre; Juravinski Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Biology; Context (archaeology); Natural killer cell; Cancer research; Immune system; Immunology; Cancer cell; Cell; Cancer; Cell biology; Cytotoxic T cell; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364455,0.0006849535,0.0009803977,0.0009802562,0.0001649827,0.0008633219,0.0006112436,0.000963361,0.001903181],"category_scores_gemma":[0.0003651292,0.0001839795,0.0003464098,0.000777606,0.0005315606,0.001130929,0.0004901642,0.001388483,0.001455698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006302936,"about_ca_system_score_gemma":0.000568995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006506466,"about_ca_topic_score_gemma":0.0009220563,"domain_scores_codex":[0.9998901,0.00001705342,0.00001175379,0.00002147161,0.00003761858,0.000021895],"domain_scores_gemma":[0.9998996,0.00004027679,0.00001576856,0.000003627308,0.00002730264,0.00001347794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001224867,0.00003924053,0.0003242071,0.009917809,0.00006054102,0.0002704644,0.00006058167,0.0004026311,0.01086976,0.007217373,0.02043208,0.9502829],"study_design_scores_gemma":[0.00001648371,0.0001375291,0.001556579,0.002127283,0.00007844193,0.001857495,0.00009888376,0.0001252641,0.003032982,0.003315508,0.9876315,0.00002209831],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000277098,0.9977081,0.0001843265,0.0002405108,0.0002943303,0.000003540556,0.00001432411,0.000008701726,0.001269024],"genre_scores_gemma":[0.001561216,0.9968232,0.0001726136,0.0002205699,0.0001519843,0.000007081957,0.00003053627,0.000002138029,0.0010307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001903181,"threshold_uncertainty_score":0.00636673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06409359377333794,"score_gpt":0.3142346709116929,"score_spread":0.2501410771383549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}