{"id":"W4392631344","doi":"10.1101/2024.03.05.583464","title":"SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Röntgen-Ångström Cluster; Stiftelsen Konung Gustaf V:s 80-årsfond; Göteborgs Universitet; Sahlgrenska Universitetssjukhuset; Vetenskapsrådet","keywords":"Survivin; Chromatin; H3K4me3; DNA damage; Cancer research; DNA repair; Cell biology; Chemistry; Histone; Molecular biology; Bivalent chromatin; Biology; Chromatin remodeling; DNA; Gene; Genetics; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008081045,0.0005715094,0.0005451187,0.0003725684,0.00006983394,0.0001557762,0.0003782196,0.0005574669,0.00001598333],"category_scores_gemma":[0.0001109191,0.0005571873,0.00009230522,0.0004716421,0.0001803404,0.000008243693,0.0007431611,0.0006393847,0.000008569073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995788,"about_ca_system_score_gemma":0.0007365206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638581,"about_ca_topic_score_gemma":0.0001713814,"domain_scores_codex":[0.9971306,0.0003493321,0.0005200645,0.00122286,0.000259312,0.0005177927],"domain_scores_gemma":[0.9983424,0.00006831004,0.000214275,0.001070295,0.0001291738,0.0001755814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003833599,0.0001182956,0.001385551,0.0004704509,0.00008639136,0.00007410818,0.00002503048,0.00092949,0.9961953,0.00003765692,0.0002916073,0.000002778942],"study_design_scores_gemma":[0.001041636,0.0002389778,0.06237267,0.001606384,0.00005545954,1.666901e-7,0.00002524723,0.002799516,0.9289454,0.000005809046,0.00195242,0.0009563382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970307,0.001479339,0.0001493237,0.0003153066,0.0002501119,0.0004615784,0.000215671,0.00008429577,0.00001371229],"genre_scores_gemma":[0.9975027,0.0006327685,0.001300384,0.0001024128,0.0001622977,0.0001277469,0.000002988802,0.0001439049,0.00002483309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06724991,"threshold_uncertainty_score":0.999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220218414642292,"score_gpt":0.22742964111621,"score_spread":0.2152274569697871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}