{"id":"W4392631344","doi":"10.1101/2024.03.05.583464","title":"SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Röntgen-Ångström Cluster; Stiftelsen Konung Gustaf V:s 80-årsfond; Göteborgs Universitet; Sahlgrenska Universitetssjukhuset; Vetenskapsrådet","keywords":"Survivin; Chromatin; H3K4me3; DNA damage; Cancer research; DNA repair; Cell biology; Chemistry; Histone; Molecular biology; Bivalent chromatin; Biology; Chromatin remodeling; DNA; Gene; Genetics; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009349905,0.0002586197,0.0002087897,0.000175047,0.0001037843,0.0002979971,0.0001550672,0.000173182,0.002107942],"category_scores_gemma":[0.00007342759,0.00009455022,0.0002020471,0.0001100274,0.0001147239,0.0001016795,0.0002364451,0.0003952156,0.0004487132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109581,"about_ca_system_score_gemma":0.0001316404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006125611,"about_ca_topic_score_gemma":0.0008119549,"domain_scores_codex":[0.9998406,0.00002466553,0.00001066207,0.00003383028,0.00003786918,0.00005232914],"domain_scores_gemma":[0.9999335,0.000005454275,0.00001583039,0.000008241365,0.00001086162,0.00002610841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316311,0.00002446767,0.0003607381,0.00003775698,0.000006417526,0.00002259672,0.000008659411,0.00007373623,0.9979207,0.00003661546,0.00004193338,0.001334631],"study_design_scores_gemma":[0.00003524789,0.0007328244,0.008687758,0.00001071266,0.0000374369,0.0001515973,0.00005370034,0.001269691,0.9849005,0.00005626293,0.004060603,0.000003666782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936028,0.002701893,0.001856375,0.00007073806,0.00004259321,0.00002161287,0.0001696918,0.00006624883,0.001467988],"genre_scores_gemma":[0.9964198,0.0004684008,0.0006159972,0.00004333616,0.00001232546,0.00001636486,0.0002890526,0.00000918559,0.002125566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002107942,"threshold_uncertainty_score":0.007051766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220218414642292,"score_gpt":0.22742964111621,"score_spread":0.2152274569697871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}