{"id":"W4392640310","doi":"10.1055/s-0044-1779183","title":"Long-Term FVIII Expression with Reduced Bleeding Following Gene Transfer for Hemophilia A: Follow-up on the Dirloctocogene Samoparvovec Phase I/II Trial","year":2024,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Term (time); Medicine; Gene transfer; Phase (matter); Internal medicine; Gene; Biology; Genetics; Chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007771956,0.0004673822,0.0006090929,0.0002254813,0.0006071922,0.0001031125,0.0002673389,0.00025085,0.0002766416],"category_scores_gemma":[0.0003047436,0.0002411811,0.0005642106,0.0004636287,0.0001752019,0.0001437594,0.00008747046,0.0004715075,0.00004763578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082814,"about_ca_system_score_gemma":0.0003852811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000747691,"about_ca_topic_score_gemma":0.000004638322,"domain_scores_codex":[0.9970319,0.0001080678,0.0004484185,0.0008417769,0.0007125487,0.0008572459],"domain_scores_gemma":[0.9981283,0.0008230908,0.00003398939,0.000639394,0.00009240569,0.0002828048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1255522,0.002178833,0.0007402252,0.000421134,0.001345703,0.003128024,0.0008047337,0.000008659114,0.8190721,0.0003564607,0.009081767,0.03731019],"study_design_scores_gemma":[0.09626046,0.01474135,0.0001173394,0.001192692,0.0008514935,0.00007129228,0.0001539202,0.000255369,0.8834083,0.0001384007,0.002373289,0.0004360852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837045,0.001212437,0.0006540243,0.006912516,0.00115366,0.005399828,0.000117929,0.0003080538,0.000537039],"genre_scores_gemma":[0.9915389,0.0001451766,0.0003481453,0.0002625546,0.0009339539,0.001190283,0.0004047074,0.0000972803,0.005078977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06433625,"threshold_uncertainty_score":0.9835082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050513912097413,"score_gpt":0.3784173083622852,"score_spread":0.2733659171525439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}