{"id":"W4392640310","doi":"10.1055/s-0044-1779183","title":"Long-Term FVIII Expression with Reduced Bleeding Following Gene Transfer for Hemophilia A: Follow-up on the Dirloctocogene Samoparvovec Phase I/II Trial","year":2024,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Term (time); Medicine; Gene transfer; Phase (matter); Internal medicine; Gene; Biology; Genetics; Chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00143187,0.0008163828,0.001370992,0.0003017584,0.0003061686,0.001384357,0.0005407275,0.00133504,0.00400218],"category_scores_gemma":[0.0007920378,0.0001876408,0.001515501,0.0003811671,0.0008029527,0.0008046945,0.0002102482,0.002510229,0.0008121302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007143227,"about_ca_system_score_gemma":0.0007431615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005741713,"about_ca_topic_score_gemma":0.001084712,"domain_scores_codex":[0.9996065,0.0001441064,0.00001773797,0.00005828506,0.00005863999,0.0001146503],"domain_scores_gemma":[0.9994923,0.0001009616,0.0001146939,0.00005128924,0.00003641905,0.0002042658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6524816,0.02458709,0.004963666,0.001971705,0.00343725,0.0005360971,0.0002492795,0.001698772,0.03057205,0.001171009,0.01503947,0.2632921],"study_design_scores_gemma":[0.6619817,0.2997035,0.01785263,0.0002977399,0.001455557,0.0007495492,0.00007280776,0.0009622208,0.005013348,0.0009953128,0.01086355,0.00005201218],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685447,0.01905927,0.0009421873,0.002192706,0.0003849018,0.001235375,0.002342897,0.0001774995,0.005120506],"genre_scores_gemma":[0.9772372,0.00789563,0.00121556,0.002311376,0.0003663568,0.001511189,0.003943221,0.00004241749,0.005477003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00400218,"threshold_uncertainty_score":0.01338863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050513912097413,"score_gpt":0.3784173083622852,"score_spread":0.2733659171525439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}