{"id":"W4392641843","doi":"10.1007/s40744-024-00651-8","title":"Real-World Effectiveness of Upadacitinib for Treatment of Rheumatoid Arthritis in Canadian Patients: Interim Results from the Prospective Observational CLOSE-UP Study","year":2024,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"ABB (Canada); Hôpital Maisonneuve-Rosemont; McMaster University; University of British Columbia; Lakeridge Health; Université de Montréal; Université Laval","funders":"AbbVie Canada","keywords":"Medicine; Rheumatoid arthritis; Interim analysis; Internal medicine; Observational study; Clinical endpoint; Adverse effect; Population; Interim; Clinical trial; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005661743,0.0001835352,0.000666412,0.0002250775,0.00009292042,0.00002030976,0.00008531551,0.00007622064,0.0000350253],"category_scores_gemma":[0.0001873937,0.000123309,0.00009604617,0.0002519463,0.0002592826,0.00008923571,0.00001307732,0.00009152001,0.000001743242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001140202,"about_ca_system_score_gemma":0.0004479018,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2125577,"about_ca_topic_score_gemma":0.2179401,"domain_scores_codex":[0.9983352,0.0003004633,0.0005557078,0.0003560396,0.0001598308,0.0002927838],"domain_scores_gemma":[0.997358,0.002039717,0.00009043988,0.0002358688,0.000174681,0.0001013397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007261373,0.0007170452,0.9383445,0.00004553811,0.0006313353,0.00001348478,0.007215137,5.692654e-7,0.0001947163,0.01093257,0.00007122848,0.03457246],"study_design_scores_gemma":[0.01933756,0.003677984,0.9638931,0.001422989,0.000002980754,0.00001341151,0.0008203337,0.00007951479,0.001884077,0.005421691,0.00332522,0.0001211696],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832865,0.01295387,0.000005704164,0.0003822111,0.0002289312,0.00232668,0.0006464061,0.00002071358,0.0001489866],"genre_scores_gemma":[0.9050839,0.09421182,0.00004060089,0.00001250878,0.000008276543,0.0003759695,0.0002297369,0.00002053287,0.00001666437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08125795,"threshold_uncertainty_score":0.7963305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331807817324633,"score_gpt":0.3287553896320766,"score_spread":0.2955746078996133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}