{"id":"W4392641843","doi":"10.1007/s40744-024-00651-8","title":"Real-World Effectiveness of Upadacitinib for Treatment of Rheumatoid Arthritis in Canadian Patients: Interim Results from the Prospective Observational CLOSE-UP Study","year":2024,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"ABB (Canada); Hôpital Maisonneuve-Rosemont; McMaster University; University of British Columbia; Lakeridge Health; Université de Montréal; Université Laval","funders":"AbbVie Canada","keywords":"Medicine; Rheumatoid arthritis; Interim analysis; Internal medicine; Observational study; Clinical endpoint; Adverse effect; Population; Interim; Clinical trial; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007016375,0.0007099041,0.00145907,0.0005620455,0.001855004,0.00142209,0.001329707,0.0008357451,0.00201907],"category_scores_gemma":[0.01112641,0.0003715096,0.002216197,0.001870079,0.000565863,0.0005603608,0.001083094,0.001329769,0.0004486567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009838603,"about_ca_system_score_gemma":0.01746429,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6822443,"about_ca_topic_score_gemma":0.7532141,"domain_scores_codex":[0.9950446,0.001140797,0.0003748764,0.0005813146,0.002177031,0.0006814442],"domain_scores_gemma":[0.986691,0.001389654,0.003899724,0.001243795,0.005117616,0.001658176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03668853,0.001457078,0.9148927,0.0007295387,0.002785609,0.0002229479,0.0009274912,0.0008783709,0.001132457,0.0002485892,0.007131533,0.03290511],"study_design_scores_gemma":[0.001781719,0.002052371,0.9906579,0.0001124244,0.0009737507,0.0001202751,0.000217707,0.0004184295,0.0002147182,0.00003769476,0.003349402,0.00006355719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627752,0.002508654,0.0003447787,0.0004688869,0.00003545954,0.0007558911,0.03035438,0.0000269475,0.002729851],"genre_scores_gemma":[0.9642086,0.0009192841,0.001089415,0.0004059978,0.00005694003,0.0004971745,0.03178531,0.00001221887,0.001025057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3177557,"threshold_uncertainty_score":0.639254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331807817324633,"score_gpt":0.3287553896320766,"score_spread":0.2955746078996133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}