{"id":"W4392641853","doi":"10.1016/j.jaci.2024.03.003","title":"Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemia","year":2024,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Foundation; Medical Research Council; Wellcome Trust","keywords":"Stem cell; Gene; Hematopoietic stem cell; Genome editing; Haematopoiesis; Biology; Genetics; Cell; Cell biology; Computational biology; CRISPR","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172047,0.000329223,0.0001913214,0.0002769215,0.0001265034,0.0002603306,0.000229419,0.0003159248,0.001028712],"category_scores_gemma":[0.0001253449,0.000105297,0.0001845773,0.0001265888,0.0002474732,0.00009483049,0.0002319218,0.0005308722,0.0002049487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001615279,"about_ca_system_score_gemma":0.0001764404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002717994,"about_ca_topic_score_gemma":0.0002920445,"domain_scores_codex":[0.9998702,0.00002386888,0.00001670578,0.00002098373,0.00004937585,0.00001895046],"domain_scores_gemma":[0.9999061,0.00002044292,0.0000334405,0.00001041766,0.00000822571,0.00002132759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130659,0.00006039797,0.0001829536,0.00005068611,0.00001194238,0.0001806672,0.00003426972,0.0003395917,0.9953482,0.0002177281,0.00006736512,0.003393193],"study_design_scores_gemma":[0.00004797809,0.0006071316,0.001324947,0.00001009876,0.00002751988,0.0004939599,0.00001801852,0.001265763,0.9932765,0.00008391933,0.002840707,0.00000359552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922895,0.0006300283,0.005399166,0.0000892269,0.00003089386,0.00006731361,0.0001829871,0.0002092928,0.001101659],"genre_scores_gemma":[0.9933743,0.0006030175,0.00397695,0.00003863879,0.000009536468,0.00003665833,0.0002328902,0.00003835617,0.001689668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028712,"threshold_uncertainty_score":0.003441393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664291088503899,"score_gpt":0.2701555419542676,"score_spread":0.2535126310692286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}