{"id":"W4392641965","doi":"10.1038/s41467-024-46371-z","title":"The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Ludwig-Maximilians-Universität München; Deutsche Forschungsgemeinschaft; York University","keywords":"Recombination-activating gene; Repertoire; Messenger RNA; Untranslated region; RNA-binding protein; T-cell receptor; Three prime untranslated region; Cell biology; RNA; Thymocyte; Biology; Molecular biology; Computational biology; Genetics; Gene; T cell; Recombination; Immune system; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158936,0.0002984102,0.0002436787,0.0002453185,0.0002539081,0.0004865199,0.0001920416,0.000225495,0.001838027],"category_scores_gemma":[0.0001215222,0.000186586,0.0002452434,0.0001349072,0.0002171478,0.0002059669,0.0002911226,0.0003517428,0.0009432799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191619,"about_ca_system_score_gemma":0.0001185877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738252,"about_ca_topic_score_gemma":0.0004193582,"domain_scores_codex":[0.9998084,0.00002769269,0.000009226846,0.00005172463,0.00006047724,0.00004266479],"domain_scores_gemma":[0.9998441,0.00002404509,0.00004855315,0.00001989693,0.00001836851,0.00004504153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001682581,0.000001913444,0.0001237725,0.000009077779,0.000001647266,0.00003167109,0.000003572521,0.00002656756,0.9990404,0.00007026512,0.00001808984,0.0006561317],"study_design_scores_gemma":[0.000005372698,0.00006122665,0.00839278,0.000005012602,0.00001207818,0.0004115234,0.00002319506,0.0009266424,0.9858774,0.0001374598,0.004142409,0.00000485996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836056,0.00322917,0.008373334,0.0001169508,0.00003468635,0.00001130253,0.0003857263,0.0003665595,0.003876515],"genre_scores_gemma":[0.9936036,0.0007064048,0.003037005,0.00004123695,0.00002128443,0.000007931203,0.0003345866,0.00006535915,0.002182524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001838027,"threshold_uncertainty_score":0.006148815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825656290129028,"score_gpt":0.287368299418753,"score_spread":0.2691117365174627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}