{"id":"W4392642743","doi":"10.1007/s11357-024-01114-2","title":"DNA methylation-based estimators of telomere length show low correspondence with paternal age at conception and other measures of external validity of telomere length","year":2024,"lang":"en","type":"article","venue":"GeroScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Center for Research Resources; Wenner-Gren Foundation; Office of Extramural Research, National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"dNaM; Telomere; Offspring; DNA methylation; Telomerase; Biology; Estimator; Methylation; Andrology; Sperm; Genetics; Demography; DNA; Statistics; Gene expression; Gene; Medicine; Pregnancy; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005027293,0.0001329982,0.0001833705,0.00008085485,0.00005052761,0.00002147863,0.0001560582,0.0000861986,0.00002130234],"category_scores_gemma":[0.0001074612,0.0001063318,0.00005291681,0.0001829676,0.0005821433,0.00001293028,0.00005302425,0.00005743629,7.271693e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000150035,"about_ca_system_score_gemma":0.0001253939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000523428,"about_ca_topic_score_gemma":0.00003994755,"domain_scores_codex":[0.9987822,0.00009019551,0.0002706822,0.0003367285,0.0003723881,0.0001478673],"domain_scores_gemma":[0.9993448,0.00006381718,0.0001900392,0.0002223894,0.0001189242,0.00005998852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008819284,0.00003062857,0.06938509,0.0001033069,0.000007576769,0.000001576174,0.0001283771,0.0009804021,0.9258047,0.00006350729,0.000004685681,0.003401915],"study_design_scores_gemma":[0.0002235016,0.0004860477,0.0389916,0.0001544644,0.00001977197,0.00000221128,0.00002550959,0.00267183,0.9570606,0.00009963748,0.0001459918,0.0001188308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611405,0.001084303,0.03738236,0.00001188229,0.0001154714,0.0001290309,0.00006256958,0.000006747065,0.00006718361],"genre_scores_gemma":[0.997477,0.00007192678,0.002261912,0.00001349649,0.00003019643,0.000005726618,0.000006008272,0.00001303503,0.0001206811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03633657,"threshold_uncertainty_score":0.4336084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03727569850708018,"score_gpt":0.2846342676903036,"score_spread":0.2473585691832234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}