{"id":"W4392642743","doi":"10.1007/s11357-024-01114-2","title":"DNA methylation-based estimators of telomere length show low correspondence with paternal age at conception and other measures of external validity of telomere length","year":2024,"lang":"en","type":"article","venue":"GeroScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Center for Research Resources; Wenner-Gren Foundation; Office of Extramural Research, National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"dNaM; Telomere; Offspring; DNA methylation; Telomerase; Biology; Estimator; Methylation; Andrology; Sperm; Genetics; Demography; DNA; Statistics; Gene expression; Gene; Medicine; Pregnancy; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004558595,0.0003502659,0.0003762966,0.001044941,0.0002553193,0.0007574676,0.0005999946,0.0005416343,0.002524386],"category_scores_gemma":[0.02276132,0.0002939061,0.0003611073,0.001168082,0.0004844742,0.0005448597,0.0006592664,0.0006666515,0.0006853777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092804,"about_ca_system_score_gemma":0.0002055765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377807,"about_ca_topic_score_gemma":0.001930546,"domain_scores_codex":[0.9977478,0.001215358,0.0001133109,0.0005078775,0.0003179629,0.00009763912],"domain_scores_gemma":[0.9698524,0.02178824,0.004248182,0.002675512,0.001009854,0.0004257541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001492225,0.00001229243,0.9862397,0.00002961527,0.0002772162,0.00002181845,0.0002237117,0.0004536035,0.005825938,0.0002396097,0.00006250777,0.006464578],"study_design_scores_gemma":[0.000003149157,0.00006940664,0.9949898,0.000004630113,0.00003538878,0.000146367,0.00007383424,0.001447053,0.002664297,0.0003298687,0.0002292131,0.000007101135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981347,0.0005885611,0.0146397,0.00007357284,0.0000154127,0.000008911779,0.0008175602,0.0000806879,0.002428608],"genre_scores_gemma":[0.9973968,0.00007149061,0.001317624,0.00002791838,0.000008953007,0.000008440253,0.0004419657,0.00002592146,0.000700876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004558595,"threshold_uncertainty_score":0.02410841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03727569850708018,"score_gpt":0.2846342676903036,"score_spread":0.2473585691832234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}