{"id":"W4392644070","doi":"10.1101/2024.02.27.580776","title":"Modelling Glioma Stem Cell-mediated Tumorigenesis Using Zebrafish PDX Systems","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Windsor","funders":"","keywords":"Zebrafish; Danio; Carcinogenesis; Glioma; Biology; Stem cell; Cancer research; Cancer stem cell; Tumor microenvironment; Phenotype; Cancer; Genetics; Gene; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572298,0.0004395525,0.0002286056,0.0003938073,0.0002227738,0.0004322001,0.000472078,0.0004711957,0.002551053],"category_scores_gemma":[0.0001122861,0.000257913,0.0003697962,0.00017792,0.000354939,0.0002450536,0.0005270354,0.000514005,0.0005456725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009645885,"about_ca_system_score_gemma":0.0005892754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007916064,"about_ca_topic_score_gemma":0.005673016,"domain_scores_codex":[0.9999129,0.000007226356,0.000004072248,0.0000158549,0.00004787213,0.00001207591],"domain_scores_gemma":[0.9999593,0.00001082618,0.00001115815,0.000004450427,0.000007739183,0.000006477656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008348913,0.00003489557,0.0009541757,0.000247342,0.00002250929,0.0003641337,0.0001117732,0.152497,0.8247178,0.01469605,0.0008600212,0.005410903],"study_design_scores_gemma":[0.00006342816,0.0003127712,0.002528633,0.00006066597,0.00004770608,0.0003166443,0.0001170237,0.4893433,0.4670903,0.004350889,0.03570342,0.00006523571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6955567,0.001706568,0.2689762,0.000584852,0.0001624461,0.0003769286,0.004180097,0.001856032,0.02660024],"genre_scores_gemma":[0.8781113,0.001929892,0.09804942,0.00004746234,0.00001434598,0.0004716231,0.001742163,0.0003498244,0.019284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007916064,"threshold_uncertainty_score":0.01573998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02074628104805745,"score_gpt":0.2469817326024464,"score_spread":0.2262354515543889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}