{"id":"W4392657848","doi":"10.3389/fimmu.2024.1353138","title":"B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; McGill Genome Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Germinal center; Deubiquitinating enzyme; Biology; B cell; Histone; Epigenetics; Antibody; Cell biology; Immunoglobulin class switching; Immune system; BAP1; T cell; Ubiquitin; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001239308,0.0003407243,0.0001686109,0.0001991581,0.0001423705,0.0003674862,0.0001897482,0.0002379795,0.002136153],"category_scores_gemma":[0.00008871074,0.0001096494,0.0002000777,0.00009897683,0.0002159015,0.0002513617,0.0003318245,0.0004210688,0.0005459154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922626,"about_ca_system_score_gemma":0.0001338742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002426434,"about_ca_topic_score_gemma":0.0002653373,"domain_scores_codex":[0.999878,0.00001282424,0.000007466044,0.00003907647,0.00003281578,0.00002977582],"domain_scores_gemma":[0.9998876,0.00001005497,0.00003635085,0.00001301386,0.00001946083,0.00003350069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005467302,0.000007097985,0.0004194661,0.00004225835,0.000004630276,0.00004824168,0.000006474115,0.00003755962,0.9980013,0.0001277978,0.00003872016,0.001211662],"study_design_scores_gemma":[0.00000954057,0.00009355499,0.01471757,0.00001028642,0.00001722384,0.0003936893,0.00002696826,0.0007190535,0.9795406,0.0001580071,0.004307987,0.000005366085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801826,0.0060668,0.008928217,0.0002317293,0.00004779534,0.00002409194,0.001060241,0.0002486614,0.003209909],"genre_scores_gemma":[0.9941754,0.001163997,0.001327544,0.0000389498,0.00001028138,0.00001395895,0.0005670245,0.00002346888,0.002679351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136153,"threshold_uncertainty_score":0.00714612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005708587227536552,"score_gpt":0.2406457877382992,"score_spread":0.2349372005107626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}