{"id":"W4392661717","doi":"10.1016/j.isci.2024.109495","title":"High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Menzies Centre for Australian Studies, King's College London, University of London; Biotechnology and Biological Sciences Research Council; Medical Research Council","keywords":"Affinity maturation; Germinal center; Monoclonal antibody; Somatic hypermutation; Epitope; Antibody; Immunization; Biology; Population; Molecular biology; B cell; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001696963,0.0002361554,0.0002776461,0.0001807644,0.00008504582,0.0003198338,0.0001713804,0.0002361358,0.0008180524],"category_scores_gemma":[0.0002048725,0.0001053079,0.0001357044,0.0001085647,0.0001084703,0.0002044233,0.0001963428,0.0006196242,0.0001805831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001195838,"about_ca_system_score_gemma":0.00009638554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001213593,"about_ca_topic_score_gemma":0.0002465716,"domain_scores_codex":[0.9998571,0.00002971001,0.000007472712,0.00002217707,0.00002694191,0.00005654295],"domain_scores_gemma":[0.9999042,0.00002860039,0.00002492958,0.00001099064,0.000009048325,0.00002225917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002585491,0.0001152009,0.0003948544,0.00002919702,0.000006494843,0.00002317899,0.00001677535,0.0001845905,0.9929371,0.00008374543,0.00004925676,0.005901028],"study_design_scores_gemma":[0.00004067525,0.002414669,0.005311802,0.000008312906,0.0000430356,0.0001873804,0.00001759783,0.00231077,0.9870114,0.00009629176,0.002552546,0.000005353771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954113,0.0008506217,0.002880234,0.00003817524,0.0000172221,0.00002751937,0.00003934553,0.00008705402,0.0006484545],"genre_scores_gemma":[0.9968451,0.0003019417,0.00214786,0.00005412082,0.00001386559,0.00001898365,0.00005766925,0.00001732518,0.0005430407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008180524,"threshold_uncertainty_score":0.002736628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007775646403905832,"score_gpt":0.2204731181244277,"score_spread":0.2126974717205219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}