{"id":"W4392661717","doi":"10.1016/j.isci.2024.109495","title":"High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Menzies Centre for Australian Studies, King's College London, University of London; Biotechnology and Biological Sciences Research Council; Medical Research Council","keywords":"Affinity maturation; Germinal center; Monoclonal antibody; Somatic hypermutation; Epitope; Antibody; Immunization; Biology; Population; Molecular biology; B cell; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000292368,0.0002115724,0.0002062065,0.0001867331,0.0006163995,0.0000998746,0.0004461849,0.0002694213,0.001176598],"category_scores_gemma":[0.0001007576,0.0001841866,0.00006338667,0.0005649123,0.0004030953,0.0003635812,0.0002664786,0.0004772786,0.001540346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001051727,"about_ca_system_score_gemma":0.000135009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002937637,"about_ca_topic_score_gemma":0.0001256675,"domain_scores_codex":[0.9984508,0.0001788703,0.0003184824,0.0005174595,0.00007287569,0.0004615163],"domain_scores_gemma":[0.9992852,0.0001088481,0.00009865246,0.0004072869,0.00007544397,0.00002461492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005598283,0.00006660428,0.0001310259,0.00003275506,0.00001656646,0.00001297249,0.0009698589,0.00002884515,0.990761,0.001204982,0.0005202221,0.006199148],"study_design_scores_gemma":[0.0003328375,0.00009035535,0.00676734,0.00007928321,0.00001823048,0.0001037338,0.0001740856,0.00006185513,0.9850928,0.001064094,0.005962568,0.0002528274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912513,0.003165923,0.0003931274,0.001044024,0.002809729,0.0001872886,0.00003216844,0.0003084376,0.0008079634],"genre_scores_gemma":[0.9944483,0.0003354717,0.0001633303,0.00007975971,0.00005674062,0.00001854477,0.0001335089,0.00001563129,0.004748738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006636315,"threshold_uncertainty_score":0.9997365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007775646403905832,"score_gpt":0.2204731181244277,"score_spread":0.2126974717205219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}