{"id":"W4392664722","doi":"10.1055/s-0044-1779102","title":"Early Changes in Liver Transcriptomic Profiles Following Adeno-Associated Viral Gene Therapy in the Severe Hemophilia A Dog Model","year":2024,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Genetic enhancement; Transcriptome; Adeno-associated virus; Gene; Virology; Medicine; Computational biology; Biology; Bioinformatics; Genetics; Gene expression; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00103777,0.0002187362,0.0004413871,0.0002378998,0.00004974961,0.00003623165,0.000251781,0.0001992734,0.00006075717],"category_scores_gemma":[0.0002852227,0.0001445961,0.0001729003,0.000342725,0.0001163132,0.000117585,0.00004748485,0.0006852563,0.00003397427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915965,"about_ca_system_score_gemma":0.000132962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511317,"about_ca_topic_score_gemma":0.0007291884,"domain_scores_codex":[0.9977887,0.0004244128,0.0003063919,0.0004204811,0.0002647807,0.000795179],"domain_scores_gemma":[0.9995121,0.0001061756,0.00002690289,0.0002455648,0.00002326643,0.00008597213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005709366,0.002054703,0.5634497,0.0006835851,0.0009685131,0.03763935,0.01767687,0.0008857052,0.2314092,0.0007959222,0.03659085,0.1021362],"study_design_scores_gemma":[0.01676212,0.009338049,0.8363055,0.001918489,0.000158868,0.0006231022,0.001738198,0.1167958,0.005346252,0.007469769,0.002437854,0.001105961],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823541,0.006047079,0.00005717616,0.01020724,0.0001233704,0.0008197589,0.0001024639,0.0001021994,0.0001865998],"genre_scores_gemma":[0.9938422,0.002734944,0.0003025555,0.002354175,0.00007927131,0.0002101079,0.0001449911,0.00002683063,0.0003048955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2728558,"threshold_uncertainty_score":0.5896457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06584798355342474,"score_gpt":0.333156619886062,"score_spread":0.2673086363326373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}