{"id":"W4392699445","doi":"10.1016/j.jaci.2024.01.031","title":"Activated sputum eosinophils associated with exacerbations in children on mepolizumab","year":2024,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; U.S. National Library of Medicine; National Institute of Allergy and Infectious Diseases; Pfizer; National Heart, Lung, and Blood Institute; National Institutes of Health; Sierra Oncology; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Sanofi; Genentech; AstraZeneca; Amgen; GlaxoSmithKline","keywords":"Mepolizumab; Sputum; Medicine; Asthma exacerbations; Immunology; Eosinophil; Asthma; Pathology; Tuberculosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005914127,0.0002473487,0.0005500402,0.0002705295,0.0002342555,0.0002992155,0.0002020624,0.00028062,0.001220664],"category_scores_gemma":[0.002298695,0.0001861141,0.0004586693,0.0003408004,0.0002162531,0.0002480065,0.0003031211,0.00061051,0.00007525782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805101,"about_ca_system_score_gemma":0.0002942544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001842057,"about_ca_topic_score_gemma":0.00227921,"domain_scores_codex":[0.9993256,0.0002204223,0.0000526495,0.0001500088,0.0001608819,0.00009044147],"domain_scores_gemma":[0.9986649,0.0002802759,0.000802786,0.0000425094,0.00007070451,0.0001389244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002531173,0.00005692694,0.9837971,0.0000993838,0.0001958627,0.0003801461,0.0001361714,0.0001265253,0.002707406,0.00005178316,0.0002839466,0.009633578],"study_design_scores_gemma":[0.00005112409,0.0003099883,0.9977163,0.00002495842,0.0001063196,0.0009384714,0.0001070118,0.0001822141,0.0003199626,0.00003039043,0.0002100142,0.00000317538],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985996,0.0009683425,0.00009067689,0.00005335375,0.000004454738,0.000008594597,0.0001234056,0.000003188769,0.0001484991],"genre_scores_gemma":[0.9994293,0.000246349,0.0001081694,0.00001966411,0.000007761254,0.000009952853,0.0001352145,0.000001693515,0.000041819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842057,"threshold_uncertainty_score":0.004083574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771717861868785,"score_gpt":0.3179919294862019,"score_spread":0.300274750867514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}