{"id":"W4392700120","doi":"10.1097/fpc.0000000000000526","title":"Association between CYP2C9 and VKORC1 genetic polymorphisms and efficacy and safety of warfarin in Chinese patients","year":2024,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"","keywords":"VKORC1; Warfarin; CYP2C9; Odds ratio; Internal medicine; Pharmacogenetics; Univariate analysis; Medicine; Vitamin K epoxide reductase; Logistic regression; Genotype; Single-nucleotide polymorphism; Biology; Multivariate analysis; Genetics; Gene; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007123554,0.0003673599,0.0004965347,0.0002654585,0.000151874,0.0000687102,0.0001335681,0.0002814692,0.00004840101],"category_scores_gemma":[0.00005083146,0.0003611557,0.00004774158,0.0002422587,0.0002131015,0.00007442274,0.0003162093,0.0005226688,0.00000409352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005802296,"about_ca_system_score_gemma":0.00006084955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003805382,"about_ca_topic_score_gemma":0.00001108677,"domain_scores_codex":[0.9978985,0.0002403655,0.000650614,0.0005598551,0.000185831,0.0004648796],"domain_scores_gemma":[0.9987276,0.0005352472,0.0001637726,0.0001200059,0.00007187267,0.0003814771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002081668,0.0001384327,0.71584,0.0001982919,0.0004476868,0.00001350235,0.001574435,0.0001580381,0.05285813,0.00008362732,0.00009985661,0.2283798],"study_design_scores_gemma":[0.006479887,0.0001537009,0.9090021,0.00003656428,0.0009366882,0.0000165843,0.00002572486,0.01325435,0.01376564,0.0009600273,0.05480976,0.000558928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534487,0.04431538,0.00004078024,0.0004037335,0.0005590368,0.0005623152,0.0004326795,0.0000275069,0.0002098644],"genre_scores_gemma":[0.9227229,0.07605772,0.0004198751,0.0003421973,0.0002558179,0.00001567735,0.00003427543,0.00004707409,0.0001044167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2278209,"threshold_uncertainty_score":0.9998841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03598974033285063,"score_gpt":0.3694414487508352,"score_spread":0.3334517084179845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}