{"id":"W4392703525","doi":"10.1093/bjd/ljae098","title":"Secukinumab in patients with moderate-to-severe hidradenitis suppurativa based on prior biologic exposure: an efficacy and safety analysis from the SUNSHINE and SUNRISE phase III trials","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Hidradenitis Suppurativa and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Barrie Urology Group","funders":"European Academy of Dermatology and Venereology; Novartis Pharma; Regeneron Pharmaceuticals; Incyte; Amgen","keywords":"Hidradenitis suppurativa; Medicine; Secukinumab; Dermatology; Sunrise; Internal medicine; Psoriasis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00382474,0.0005690427,0.001787812,0.0003185709,0.0003114734,0.0008013632,0.0004028201,0.0007450823,0.002251558],"category_scores_gemma":[0.001750003,0.0002930427,0.002818502,0.000400677,0.0004348984,0.0005344643,0.00032625,0.001485941,0.000247646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003697874,"about_ca_system_score_gemma":0.0005669349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002126828,"about_ca_topic_score_gemma":0.001074209,"domain_scores_codex":[0.9988503,0.0007009091,0.000144618,0.00009658667,0.0001104802,0.00009691682],"domain_scores_gemma":[0.9981266,0.0006958668,0.0005627688,0.0001243404,0.0001247556,0.0003657794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7826058,0.007287549,0.03648665,0.00494663,0.01067241,0.0002452717,0.0001961625,0.001246419,0.01434924,0.0003089626,0.002682772,0.1389721],"study_design_scores_gemma":[0.5852156,0.2649439,0.126372,0.0008232254,0.008075715,0.0009147738,0.0001445836,0.001510014,0.003088211,0.0005311416,0.008312614,0.0000682786],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9393374,0.05370785,0.0005065436,0.000823517,0.0002231571,0.00136873,0.0008820323,0.00004113244,0.00310957],"genre_scores_gemma":[0.9907838,0.006189877,0.0003741505,0.0007069291,0.0001614171,0.0005300489,0.0008752549,0.000005848246,0.0003726109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00382474,"threshold_uncertainty_score":0.02022743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816705882763973,"score_gpt":0.2935851276832833,"score_spread":0.2754180688556436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}