{"id":"W4392706606","doi":"10.1002/rcm.9731","title":"Perturbations in human bile acid profiles following drug‐induced liver injury investigated using semitargeted high‐resolution mass spectrometry","year":2024,"lang":"en","type":"article","venue":"Rapid Communications in Mass Spectrometry","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta; Université de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université du Québec à Montréal","keywords":"Chemistry; Taurine; Chromatography; Acetaminophen; Mass spectrometry; Liver injury; Glucuronide; Sulfation; Resolution (logic); Tandem mass spectrometry; Drug metabolism; Urine; Pharmacology; Metabolism; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002377949,0.0004899513,0.0005653807,0.003104656,0.0009369415,0.0001633704,0.001181863,0.0007363145,0.0007852562],"category_scores_gemma":[0.0003232014,0.0005670952,0.0002652653,0.005687029,0.0002947321,0.0007497289,0.0003189931,0.003832813,0.00009859979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001923788,"about_ca_system_score_gemma":0.000322695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007077518,"about_ca_topic_score_gemma":0.0003214896,"domain_scores_codex":[0.9947565,0.002244412,0.00102058,0.0007455037,0.0003586144,0.0008744152],"domain_scores_gemma":[0.9974375,0.0007536641,0.0002222239,0.001281741,0.00009019599,0.0002146344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004133406,0.000427174,0.007054672,0.0001236265,0.0002106063,0.00004084975,0.001229767,0.0004588369,0.9803574,0.008512937,0.000212984,0.001329777],"study_design_scores_gemma":[0.002156893,0.0003063928,0.01582016,0.0006840755,0.0003405496,0.00004241972,0.001619111,0.2347499,0.7136751,0.0246499,0.004360507,0.001594973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849967,0.005379328,0.001637629,0.001667609,0.001315262,0.001333175,0.0001052829,0.0005398152,0.003025234],"genre_scores_gemma":[0.976031,0.001038464,0.02148375,0.0002241657,0.0002299641,0.0003670637,0.0002991541,0.00008912575,0.0002373041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2666823,"threshold_uncertainty_score":0.9996781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1245864197593121,"score_gpt":0.4071980311951414,"score_spread":0.2826116114358292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}