{"id":"W4392708717","doi":"10.3390/biology13030180","title":"Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models","year":2024,"lang":"en","type":"article","venue":"Biology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Servier","keywords":"Thioredoxin; Glutaredoxin; Biology; Thioredoxin reductase; Cell biology; Glutathione; Transgene; Genetically modified mouse; Function (biology); Reactive oxygen species; Antioxidant; Cysteine; Biochemistry; Oxidative stress; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378049,0.0001806844,0.0002125871,0.00006646007,0.00009430682,0.00001071368,0.0003137984,0.0002478331,0.000006365677],"category_scores_gemma":[0.00004278199,0.0001085947,0.0001146368,0.0001085936,0.0003146411,0.000007236235,0.0002054255,0.000134503,0.00001726225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000130796,"about_ca_system_score_gemma":0.00005168769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006020356,"about_ca_topic_score_gemma":0.00008001251,"domain_scores_codex":[0.9988679,0.0002055856,0.0002683945,0.0004053903,0.00004853659,0.0002042295],"domain_scores_gemma":[0.9993902,0.00005564649,0.00006381776,0.0003770301,0.00007284623,0.00004050153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007449176,0.00001980515,0.000308991,0.00008910309,0.0001863809,0.000004873298,0.0008497455,0.0001790665,0.9742504,0.01639669,0.0001285048,0.007511897],"study_design_scores_gemma":[0.0003431429,0.0004085822,0.0009491115,0.000114221,0.0000450828,0.00001659802,0.001394413,0.002419546,0.9587901,0.001454573,0.03380443,0.0002601821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759369,0.01870835,0.002961033,0.0001311514,0.0006017592,0.0001820103,0.00001809018,0.00004631237,0.001414369],"genre_scores_gemma":[0.9980164,0.000995915,0.0002161071,0.00004123544,0.0002942345,0.00008520107,0.000126541,0.00001752528,0.0002068103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03367593,"threshold_uncertainty_score":0.4428364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02905343474310254,"score_gpt":0.2697614588581502,"score_spread":0.2407080241150477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}