{"id":"W4392708717","doi":"10.3390/biology13030180","title":"Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models","year":2024,"lang":"en","type":"article","venue":"Biology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Servier","keywords":"Thioredoxin; Glutaredoxin; Biology; Thioredoxin reductase; Cell biology; Glutathione; Transgene; Genetically modified mouse; Function (biology); Reactive oxygen species; Antioxidant; Cysteine; Biochemistry; Oxidative stress; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008036657,0.0009219561,0.000690809,0.001789308,0.0003622717,0.0007818469,0.0008552818,0.0009219662,0.00251826],"category_scores_gemma":[0.0003585559,0.0003418428,0.0005570782,0.0005624418,0.0007503823,0.0008632549,0.0004601486,0.001694561,0.0007363542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004901458,"about_ca_system_score_gemma":0.0004830451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003677972,"about_ca_topic_score_gemma":0.000596873,"domain_scores_codex":[0.9996543,0.00006635751,0.00005567119,0.00008870299,0.00009101225,0.0000438968],"domain_scores_gemma":[0.9997275,0.00007288023,0.00008853326,0.00002569621,0.0000388096,0.00004643439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005239536,0.0003667212,0.000958305,0.001068419,0.0001114623,0.001013713,0.0001206715,0.0003956171,0.9607769,0.00600328,0.001438159,0.02722286],"study_design_scores_gemma":[0.0004297565,0.005127165,0.009747257,0.001363261,0.001476233,0.0143079,0.0003889857,0.003728244,0.7486091,0.008420301,0.2062769,0.0001248778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6432408,0.1558647,0.1651654,0.004863509,0.0009496504,0.0009187714,0.008235283,0.002200722,0.0185611],"genre_scores_gemma":[0.5929492,0.264003,0.1053067,0.00208097,0.0003189656,0.001341006,0.009482915,0.0006005178,0.02391687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00251826,"threshold_uncertainty_score":0.008424461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02905343474310254,"score_gpt":0.2697614588581502,"score_spread":0.2407080241150477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}