{"id":"W4392714786","doi":"10.2174/0115672050301583240307114452","title":"Drug Design for Alzheimer’s Disease: Biologics vs. Small Molecules","year":2023,"lang":"en","type":"review","venue":"Current Alzheimer Research","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Krembil Foundation","keywords":"Magic bullet; Polypharmacy; MAGIC (telescope); Medicine; Alzheimer's disease; Disease; Drug; Small molecule; Pharmacology; Neuroscience; Psychology; Bioinformatics; Chemistry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00130429,0.001159811,0.002090924,0.002423468,0.0003022089,0.001407592,0.001332296,0.001585261,0.003379024],"category_scores_gemma":[0.001241719,0.0004975764,0.0007972,0.002881003,0.0009931859,0.002223915,0.0008431005,0.003762067,0.002604325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074004,"about_ca_system_score_gemma":0.001058631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001461967,"about_ca_topic_score_gemma":0.002184772,"domain_scores_codex":[0.9995927,0.00009945121,0.00004362351,0.00005964993,0.0001675009,0.00003709404],"domain_scores_gemma":[0.9992968,0.0004335889,0.00007079251,0.00002477635,0.0001306293,0.00004334019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001043148,0.0001316204,0.0001354655,0.01764119,0.0001743482,0.0001266969,0.00007118388,0.001395134,0.001538985,0.01975124,0.03590036,0.9230295],"study_design_scores_gemma":[0.00006641834,0.0001689426,0.0003273524,0.005422621,0.00009808657,0.0006069122,0.00004728289,0.0004325034,0.0005062644,0.01153495,0.9807612,0.0000275966],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001045233,0.9979449,0.0003882684,0.0004471981,0.0001889375,0.000008313997,0.00001460983,0.00001214757,0.0008911021],"genre_scores_gemma":[0.0006791098,0.9975298,0.0005617481,0.0004243054,0.0001421406,0.00001343115,0.00002300556,0.000003907021,0.0006225361],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003379024,"threshold_uncertainty_score":0.01130396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7187284328559562,"score_gpt":0.555246614755921,"score_spread":0.1634818181000353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}