{"id":"W4392730906","doi":"10.1124/jpet.123.002000","title":"N-Acetylcysteine Alters Disease Progression and Increases Janus Kinase Mutation Frequency in a Mouse Model of Precursor B-Cell Acute Lymphoblastic Leukemia","year":2024,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Acetylcysteine; Leukemia; Cancer research; CD19; PTEN; Biology; B cell; Immunology; Medicine; Molecular biology; Apoptosis; Antigen; Antibody; Antioxidant; PI3K/AKT/mTOR pathway; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840291,0.00084472,0.0005565525,0.001684562,0.0004461242,0.0006107431,0.000606169,0.0009423188,0.001932163],"category_scores_gemma":[0.000251353,0.000443696,0.0004726683,0.0005966517,0.0008528547,0.0005081209,0.0002536746,0.001720844,0.0004591247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006895402,"about_ca_system_score_gemma":0.0004763851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185504,"about_ca_topic_score_gemma":0.001662866,"domain_scores_codex":[0.9994764,0.0001497781,0.00005871125,0.00008161976,0.0001214057,0.0001121081],"domain_scores_gemma":[0.9994405,0.00008000083,0.0002118278,0.00006026123,0.00002745909,0.0001799396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001836289,0.0007573084,0.0004126634,0.00004346482,0.00001847338,0.0001889802,0.00003934629,0.0001950901,0.9949351,0.0002749132,0.00009656612,0.001201914],"study_design_scores_gemma":[0.0004672725,0.004672026,0.004333558,0.00001975829,0.00009031036,0.0006972823,0.0001365078,0.001822623,0.9852586,0.0002418878,0.00224059,0.00001962917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969318,0.0005828531,0.0008802103,0.0002123,0.00004847132,0.00005792529,0.0004416935,0.0001675294,0.000677203],"genre_scores_gemma":[0.9942163,0.0008376827,0.001438703,0.00008299796,0.00001945099,0.0001252053,0.0004183875,0.00005866636,0.002802546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001932163,"threshold_uncertainty_score":0.006463766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090469617040965,"score_gpt":0.3502494226626312,"score_spread":0.3293447264922216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}