{"id":"W4392735610","doi":"10.1002/acr2.11610","title":"Safety, Tolerability, and Pharmacodynamics of the ADAMTS‐5 Nanobody M6495: Two Phase 1, Single‐Center, Double‐Blind, Randomized, Placebo‐Controlled Studies in Healthy Subjects and Patients With Osteoarthritis","year":2024,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck KGaA","keywords":"Medicine; Pharmacodynamics; Placebo; Tolerability; Pharmacokinetics; Nausea; Single Center; Osteoarthritis; Adverse effect; Pharmacology; Internal medicine; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001320981,0.0007064043,0.001157886,0.0002222438,0.0002586086,0.00045591,0.0003694094,0.0009473266,0.001248986],"category_scores_gemma":[0.001115658,0.0004339249,0.0007735699,0.0001845625,0.0006631843,0.0005301681,0.0001876789,0.001048085,0.0002798452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184015,"about_ca_system_score_gemma":0.0004132054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029546,"about_ca_topic_score_gemma":0.0004433127,"domain_scores_codex":[0.9994135,0.0003197399,0.00005491819,0.00008967522,0.00007413295,0.00004810554],"domain_scores_gemma":[0.9990515,0.0002474582,0.0003960362,0.00006228147,0.00005850178,0.0001842534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7623023,0.02152265,0.01176976,0.001184426,0.001636656,0.000246393,0.0002834426,0.0009691861,0.124916,0.00009289048,0.0007317308,0.07434477],"study_design_scores_gemma":[0.2552781,0.6958069,0.03132548,0.00004724021,0.001095924,0.0004223247,0.0000908797,0.0009636195,0.01390458,0.0000905437,0.0009326534,0.00004155292],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978859,0.00142063,0.0002088434,0.00005648942,0.00002333209,0.0001604086,0.00007379043,0.00001390549,0.0001567193],"genre_scores_gemma":[0.9985166,0.0005444547,0.0002914887,0.0001292145,0.00005470771,0.0001534705,0.0001084542,0.000003397901,0.0001981523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320981,"threshold_uncertainty_score":0.006986141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458173665412834,"score_gpt":0.3255580279512069,"score_spread":0.3009762912970786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}