{"id":"W4392739328","doi":"10.1093/ibd/izae036","title":"Attenuation of Colitis-Induced Visceral Hypersensitivity and Pain by Selective Silencing of TRPV1-Expressing Fibers in Rat Colon","year":2024,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Israel Science Foundation; Deutsche Forschungsgemeinschaft; International Development Research Centre","keywords":"TRPV1; Transient receptor potential channel; Colitis; Nociceptor; Visceral pain; Capsaicin; Pharmacology; Nociception; Inflammatory bowel disease; Medicine; Chemistry; Immunology; Receptor; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225589,0.0005274188,0.0003835974,0.0003159892,0.0001567096,0.0001734004,0.0002542058,0.0003600547,0.001544968],"category_scores_gemma":[0.000151706,0.0002218443,0.0003531939,0.000138381,0.0003903921,0.0004022461,0.0001428158,0.0008075028,0.0003273327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307178,"about_ca_system_score_gemma":0.000323566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005398217,"about_ca_topic_score_gemma":0.0006902438,"domain_scores_codex":[0.9998664,0.00001476462,0.00001345122,0.00003737873,0.00002640372,0.00004156923],"domain_scores_gemma":[0.9998368,0.00002163051,0.00006074248,0.00001740368,0.00001686047,0.00004657953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002464681,0.00006036137,0.0000586326,0.00004442389,0.000003109667,0.00001883287,0.00001229426,0.00003323653,0.9988116,0.00002724699,0.00001053207,0.0006733194],"study_design_scores_gemma":[0.00007082822,0.00295661,0.00288099,0.00001058089,0.00003097249,0.000137451,0.00004098613,0.0006269162,0.9926401,0.00003227403,0.0005669739,0.000005245119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951273,0.001336321,0.002651321,0.00009492201,0.00004410589,0.0000402654,0.0001241658,0.00008798749,0.0004935962],"genre_scores_gemma":[0.9928159,0.001577333,0.003164603,0.00005146201,0.0000216723,0.00009848706,0.0002053612,0.00001960186,0.002045566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544968,"threshold_uncertainty_score":0.005168498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383843435494381,"score_gpt":0.2480092687811175,"score_spread":0.2341708344261737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}