{"id":"W4392740871","doi":"10.7554/elife.88559.3.sa0","title":"eLife assessment: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Locus coeruleus; Hippocampal formation; Locus (genetics); Norepinephrine; Gene; Neuroscience; Chemistry; Biology; Genetics; Central nervous system; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001441331,0.0002618635,0.0003359734,0.0009020912,0.0007136358,0.00134876,0.0006642026,0.0005051984,0.01812101],"category_scores_gemma":[0.003032925,0.0002263979,0.0002042916,0.0006360675,0.0007483927,0.00102793,0.001350718,0.001004021,0.007459984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008950057,"about_ca_system_score_gemma":0.002242494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003834299,"about_ca_topic_score_gemma":0.01943208,"domain_scores_codex":[0.9989845,0.00008492577,0.00005045255,0.0001361257,0.0006211131,0.0001227748],"domain_scores_gemma":[0.9966446,0.0002890847,0.0003444224,0.0002453215,0.001971037,0.0005055141],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005051466,0.0001046466,0.009162188,0.0009324243,0.00009884924,0.001399569,0.0008416758,0.0006754012,0.606287,0.008502091,0.117127,0.2543641],"study_design_scores_gemma":[0.00008162198,0.0001694474,0.03473704,0.0001911859,0.00008683113,0.0008620518,0.001126419,0.002018845,0.3044524,0.003901117,0.6523181,0.0000550755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.5404907,0.01665406,0.1278542,0.04158186,0.01017166,0.001271504,0.02311661,0.01094134,0.2279181],"genre_scores_gemma":[0.5790731,0.01018848,0.05449621,0.002633959,0.001025276,0.00047834,0.01203828,0.00230825,0.3377582],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9985586,"threshold_uncertainty_score":0.06062078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642430093221453,"score_gpt":0.3133504575470589,"score_spread":0.2869261566148444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}