{"id":"W4392743061","doi":"10.1016/j.ebiom.2024.105040","title":"Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"NHLBI Division of Intramural Research; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Mental Health; National Institutes of Health; Ontario Genomics; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"Virology; Integrase inhibitor; Integrase; Replication (statistics); Regimen; Human immunodeficiency virus (HIV); Viral replication; Lentivirus; Medicine; Virus; Biology; Antiretroviral therapy; Immunology; Viral load; Viral disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001672331,0.0002835442,0.0002785276,0.000160559,0.0001600054,0.0008711992,0.0004444428,0.0003859547,0.001908466],"category_scores_gemma":[0.005396144,0.0002173404,0.0004257267,0.0001954273,0.0002811331,0.0004630838,0.0003711848,0.0009956501,0.0002555528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000685094,"about_ca_system_score_gemma":0.0005270766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003125404,"about_ca_topic_score_gemma":0.00245773,"domain_scores_codex":[0.9996214,0.000112231,0.0000214471,0.0001100215,0.00005987226,0.00007503456],"domain_scores_gemma":[0.9976428,0.001400119,0.0005431732,0.0001664607,0.0001417739,0.0001056655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003126925,0.0002642946,0.8395252,0.0003644651,0.0007490091,0.0007544687,0.0008192825,0.05352061,0.04736714,0.00180548,0.001180109,0.05052308],"study_design_scores_gemma":[0.0001314999,0.00242555,0.7737859,0.0001976076,0.0007321911,0.002059874,0.0007075238,0.1851337,0.02680711,0.004136404,0.003798709,0.00008392199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929659,0.0003885283,0.005154584,0.0001209284,0.000008531705,0.00002324727,0.0005179984,0.00007376575,0.0007465251],"genre_scores_gemma":[0.998931,0.00004793571,0.0005020106,0.00004368457,0.000002655931,0.00000872806,0.0002738403,0.000005462954,0.0001847363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003125404,"threshold_uncertainty_score":0.008844197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461138141810146,"score_gpt":0.2787505596021803,"score_spread":0.2641391781840788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}