{"id":"W4392744338","doi":"10.1056/nejmoa2304714","title":"A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"National Cancer Institute","keywords":"Medicine; Colorectal cancer; Colonoscopy; Internal medicine; Oncology; Cancer; Population; Blood test; Confidence interval; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273686,0.0001101161,0.0001824777,0.00007069515,0.00003400336,0.00001899676,0.0001656544,0.00006572611,0.00004391534],"category_scores_gemma":[0.0005779032,0.00008063201,0.00008878104,0.00006931455,0.00004749167,0.000002504601,0.00002505372,0.000115447,3.722816e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001369059,"about_ca_system_score_gemma":0.0003982485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006649257,"about_ca_topic_score_gemma":0.0001156094,"domain_scores_codex":[0.9993036,0.00001258327,0.0002587937,0.0001317524,0.0001409912,0.0001522145],"domain_scores_gemma":[0.9992447,0.0002627254,0.0001016346,0.0001093274,0.0001251428,0.0001564034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006783155,0.0000667783,0.003024068,0.0001164868,0.0001661933,0.00009448742,0.0001375055,0.00075571,0.7417582,0.00004886446,0.2018458,0.0513076],"study_design_scores_gemma":[0.03809792,0.005433446,0.0007315027,0.0005141748,0.0005254033,0.0002261889,0.00005262285,0.0009829098,0.265349,0.000357189,0.6875131,0.0002165894],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.919721,0.04431997,0.0226856,0.01046074,0.001855343,0.000221792,0.0001359091,0.000009903891,0.000589721],"genre_scores_gemma":[0.9850124,0.001408539,0.002259083,0.0006605245,0.0102826,0.00000625222,0.00002644911,0.00002609837,0.0003180839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4856673,"threshold_uncertainty_score":0.3288078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103207782922854,"score_gpt":0.2629577856955955,"score_spread":0.2526370074033101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}