{"id":"W4392746654","doi":"10.7554/elife.95151","title":"Un1Cas12f1 and Cas9 gene drive in HSV1: viruses that ‘infect’ viruses","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"","keywords":"CRISPR; Cas9; Gene; Biology; Genome editing; Gene drive; Genetics; Computational biology; Virology; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004567818,0.0003955501,0.0003772241,0.0003489421,0.0002653315,0.0009268894,0.0004791429,0.0005459764,0.001623737],"category_scores_gemma":[0.0004841468,0.0002520307,0.0002596643,0.0002527273,0.0004341595,0.0005235805,0.0005618912,0.001064915,0.0007771697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008739562,"about_ca_system_score_gemma":0.0004183235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001770149,"about_ca_topic_score_gemma":0.001551845,"domain_scores_codex":[0.9995233,0.00005332727,0.00003795477,0.0001058982,0.0001961601,0.0000833923],"domain_scores_gemma":[0.999697,0.00005409721,0.0001014715,0.000046883,0.00004752276,0.00005314527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006191595,0.00002016633,0.0005264936,0.00008689738,0.00001075447,0.00006415402,0.00003746878,0.0005347699,0.9923644,0.001526195,0.0002680465,0.00449881],"study_design_scores_gemma":[0.000003454102,0.00003683718,0.0007145697,0.000008418549,0.00000584141,0.0001736226,0.00002166389,0.002027472,0.9893066,0.0002259305,0.00746589,0.000009598471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9089884,0.004938913,0.07191372,0.0005707602,0.0003838633,0.0001422226,0.00172609,0.001119217,0.01021685],"genre_scores_gemma":[0.9551324,0.001210894,0.03227989,0.00009917474,0.0000184556,0.00006188548,0.001074405,0.0003217248,0.009801115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770149,"threshold_uncertainty_score":0.006340981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205726537110784,"score_gpt":0.329676500921716,"score_spread":0.3091038472106376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}