{"id":"W4392751576","doi":"10.1177/02698811241238284","title":"Brain-derived neurotrophic factor Val66Met and CYP2B6 polymorphisms as predictors for ketamine effectiveness in patients with treatment-resistant depression","year":2024,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brain and Cognition Discovery Foundation; University of Toronto; University of Windsor","funders":"","keywords":"Ketamine; Anxiety; Antidepressant; Clinical psychology; Medicine; Psychology; Depression (economics); Psychiatry; Major depressive disorder; Suicidal ideation; Oncology; Internal medicine; Mood; Poison control; Injury prevention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644378,0.0002997632,0.0006151025,0.0005448638,0.00005349529,0.00002581781,0.00008628437,0.0001379089,0.00009845728],"category_scores_gemma":[0.00007467219,0.0001828704,0.0001509031,0.0002041923,0.00008278069,0.000185469,0.00002234762,0.0002582163,0.00000333733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466865,"about_ca_system_score_gemma":0.0001525572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001165578,"about_ca_topic_score_gemma":0.000002641553,"domain_scores_codex":[0.9983597,0.0002200312,0.0004544542,0.0003683865,0.0003019506,0.0002954923],"domain_scores_gemma":[0.998566,0.0006882956,0.0002252059,0.0001418591,0.0001233928,0.0002552661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05376347,0.001802609,0.5347475,0.0002994881,0.0009619871,0.0009772666,0.0002543152,0.00002127811,0.3941217,0.000004528677,0.0005763226,0.01246952],"study_design_scores_gemma":[0.03939031,0.01500379,0.9285957,0.0006326211,0.0006629433,0.0001981389,0.00000880921,0.00005167523,0.01412665,0.00004546324,0.001141226,0.0001426383],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937289,0.002772939,0.0001026348,0.0008351605,0.001114455,0.0013344,0.00004147748,0.00003505918,0.00003495618],"genre_scores_gemma":[0.9987743,0.00021899,0.0002956513,0.0002522158,0.0002306175,0.00007000546,0.00001397707,0.0000596548,0.00008460983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3938482,"threshold_uncertainty_score":0.7457238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045461036536969,"score_gpt":0.3106877682985786,"score_spread":0.3002331579332089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}