{"id":"W4392768297","doi":"10.1016/j.jhazmat.2024.134017","title":"ROS-dependent degeneration of human neurons induced by environmentally relevant levels of micro- and nanoplastics of diverse shapes and forms","year":2024,"lang":"en","type":"article","venue":"Journal of Hazardous Materials","topic":"Microplastics and Plastic Pollution","field":"Environmental Science","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Okanagan University College; Kelowna General Hospital; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canada Research Coordinating Committee","keywords":"Neurodegeneration; Oxidative stress; Human health; Human brain; Neurotoxicity; Chemistry; Neuroscience; Cell biology; Biology; Medicine; Toxicity; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412216,0.0003503389,0.0001663665,0.0002003074,0.0001358407,0.0002103908,0.0001594732,0.0003489143,0.0009806757],"category_scores_gemma":[0.0001645147,0.0001308536,0.0002219907,0.0001111578,0.0001683379,0.0002101983,0.0002606642,0.0003581871,0.0002259069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126271,"about_ca_system_score_gemma":0.0001977951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007798828,"about_ca_topic_score_gemma":0.002012363,"domain_scores_codex":[0.99986,0.00002038453,0.00002017015,0.00003503207,0.00004266495,0.00002173641],"domain_scores_gemma":[0.9999048,0.00001877902,0.00002496171,0.00001358102,0.00002848956,0.000009504986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006770034,0.00002810747,0.0004932024,0.00006907743,0.000007959675,0.00009217262,0.00003040635,0.00009065167,0.997745,0.00002924186,0.00002760446,0.001318946],"study_design_scores_gemma":[0.000003054119,0.0003608545,0.004358515,0.00001266294,0.00001652401,0.0001805739,0.00006786993,0.0003819965,0.9937162,0.00006984328,0.0008277011,0.000004256333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989907,0.002006156,0.005187718,0.0001146551,0.00004767005,0.00006671829,0.0005997718,0.0000583421,0.002012062],"genre_scores_gemma":[0.9908504,0.001622555,0.004504874,0.000101793,0.000007866881,0.00009000885,0.0003839744,0.00001562009,0.002422883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009806757,"threshold_uncertainty_score":0.003280699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329773393040359,"score_gpt":0.2225382867436607,"score_spread":0.2092405528132571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}