{"id":"W4392779637","doi":"10.1016/j.xcrp.2024.101869","title":"Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms","year":2024,"lang":"en","type":"article","venue":"Cell Reports Physical Science","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; National Institute of Allergy and Infectious Diseases; Perelman School of Medicine, University of Pennsylvania; Defense Threat Reduction Agency; National Taiwan University Hospital; National Institutes of Health; Queen's University; ACE Foundation; Brain and Behavior Research Foundation; University of Georgia; National Science Foundation; Procter and Gamble; Welch Foundation; University of Pennsylvania; Queen's University Belfast; National Institute of General Medical Sciences; United Therapeutics Corporation","keywords":"Klebsiella pneumoniae; Polyproline helix; Microbiology; Biofilm; Polysaccharide; Peptide; Chemistry; Biology; Bacteria; Biochemistry; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162617,0.00027658,0.0001649408,0.0001134105,0.00009623144,0.0001881957,0.0001587067,0.0004225282,0.000909056],"category_scores_gemma":[0.0001209834,0.0001177873,0.0001541977,0.00005560085,0.0001875274,0.0001860673,0.0001903632,0.0004754161,0.0002448217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502269,"about_ca_system_score_gemma":0.0001293873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002070359,"about_ca_topic_score_gemma":0.0003576269,"domain_scores_codex":[0.9998953,0.0000196381,0.00000523933,0.00001896186,0.00003271183,0.00002816119],"domain_scores_gemma":[0.9999169,0.0000247225,0.00001626908,0.000005982251,0.00001489507,0.00002127034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002306791,0.000008592968,0.00002626716,0.00001655679,0.000001071391,0.00001889668,0.000003541663,0.0000293264,0.9993772,0.0000188892,0.000009067323,0.0004675856],"study_design_scores_gemma":[0.000007704819,0.0003991705,0.001493989,0.000004162452,0.000003337025,0.0001857756,0.00001076443,0.0004877988,0.9966372,0.0000228625,0.0007444173,0.000002728665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948997,0.001540189,0.002179432,0.00006969763,0.00002378765,0.00002688667,0.00005957474,0.00001985299,0.001180879],"genre_scores_gemma":[0.9941043,0.0008258179,0.003446544,0.00009985633,0.00001176026,0.00002384453,0.0001257917,0.000008365558,0.001353673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000909056,"threshold_uncertainty_score":0.003041089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007470125151134853,"score_gpt":0.2433542366479545,"score_spread":0.2358841114968196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}