{"id":"W4392779637","doi":"10.1016/j.xcrp.2024.101869","title":"Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms","year":2024,"lang":"en","type":"article","venue":"Cell Reports Physical Science","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; National Institute of Allergy and Infectious Diseases; Perelman School of Medicine, University of Pennsylvania; Defense Threat Reduction Agency; National Taiwan University Hospital; National Institutes of Health; Queen's University; ACE Foundation; Brain and Behavior Research Foundation; University of Georgia; National Science Foundation; Procter and Gamble; Welch Foundation; University of Pennsylvania; Queen's University Belfast; National Institute of General Medical Sciences; United Therapeutics Corporation","keywords":"Klebsiella pneumoniae; Polyproline helix; Microbiology; Biofilm; Polysaccharide; Peptide; Chemistry; Biology; Bacteria; Biochemistry; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003482673,0.0002526065,0.0003089152,0.0001892549,0.0004163986,0.0001988992,0.0003369861,0.00008174669,0.0001938139],"category_scores_gemma":[0.00007986086,0.0001983403,0.0001589793,0.00087687,0.000898156,0.0003425909,0.0002943093,0.0002792807,0.0009712768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007729591,"about_ca_system_score_gemma":0.0003293933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709118,"about_ca_topic_score_gemma":0.000007098583,"domain_scores_codex":[0.9979268,0.00002577254,0.0003089217,0.0008643884,0.0001310255,0.0007430705],"domain_scores_gemma":[0.9992152,0.00009087843,0.00006429556,0.0004231778,0.00008230507,0.0001240726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001109961,0.0001267355,0.0001423324,0.0000228146,0.00001283813,0.0001961979,0.0004886832,0.00003505349,0.9879788,0.0007676677,0.008351964,0.001865866],"study_design_scores_gemma":[0.0000565416,0.0001442014,0.0004415123,0.0000556608,0.0000228973,0.0002506598,0.000142042,0.00006620769,0.9584316,0.0004022286,0.03969285,0.0002935912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865305,0.0007102211,0.000120975,0.000616973,0.001663989,0.000270546,0.00002109675,0.000236593,0.009829151],"genre_scores_gemma":[0.9843308,0.00001885282,0.0001281052,0.0002996435,0.000180412,0.00001612926,0.00001033944,0.00002238097,0.01499336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03134089,"threshold_uncertainty_score":0.9998066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007470125151134853,"score_gpt":0.2433542366479545,"score_spread":0.2358841114968196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}