{"id":"W4392784136","doi":"10.1002/advs.202307237","title":"Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Genentech; Bayer; Institute of Cancer Research; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; Structural Genomics Consortium; Merck KGaA; Else Kröner-Fresenius-Stiftung; Ontario Genomics; Genome Canada; Pfizer; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Histamine; Itching; Pharmacology; Potassium channel; Scratching; In vivo; Antipruritic; Activator (genetics); Medicine; Pharmacodynamics; Receptor; Chemistry; Pharmacokinetics; Internal medicine; Materials science; Dermatology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002841301,0.0001261717,0.0003440662,0.0002752674,0.00003372276,0.00001612129,0.0001907665,0.00004815797,0.000003787438],"category_scores_gemma":[0.0001346182,0.0001043993,0.00005383474,0.0004585786,0.0007043657,0.0007395179,0.00009385927,0.0001349533,5.09e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009050826,"about_ca_system_score_gemma":0.000663314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003074608,"about_ca_topic_score_gemma":0.00001173025,"domain_scores_codex":[0.9986479,0.00002845802,0.0002999528,0.000381889,0.0003942175,0.0002476053],"domain_scores_gemma":[0.9993913,0.0001104722,0.0001244003,0.0002082016,0.00008769841,0.0000778926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147295,0.0001336346,0.001108379,0.0005160055,0.00001499344,0.00004096611,0.0005794163,0.002187029,0.9942325,0.0005176059,0.00002125512,0.0005008621],"study_design_scores_gemma":[0.0005258282,0.0001066669,0.001856552,0.000668949,0.00002247276,0.00002212644,0.0005845486,0.01371073,0.9811539,0.001241494,0.000004174784,0.0001025374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948024,0.002861484,0.00121071,0.0001605352,0.000102949,0.000245985,0.00003815938,0.00001599679,0.0005617609],"genre_scores_gemma":[0.999109,0.0002002023,0.0003307805,0.00002835563,0.00001058705,0.00001319857,0.000002853405,0.00001044554,0.0002945622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01307864,"threshold_uncertainty_score":0.4257282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153934400697402,"score_gpt":0.2804760363080878,"score_spread":0.2589366923011138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}