{"id":"W4392784136","doi":"10.1002/advs.202307237","title":"Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Genentech; Bayer; Institute of Cancer Research; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; Structural Genomics Consortium; Merck KGaA; Else Kröner-Fresenius-Stiftung; Ontario Genomics; Genome Canada; Pfizer; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Histamine; Itching; Pharmacology; Potassium channel; Scratching; In vivo; Antipruritic; Activator (genetics); Medicine; Pharmacodynamics; Receptor; Chemistry; Pharmacokinetics; Internal medicine; Materials science; Dermatology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001448986,0.0003666222,0.0003038021,0.0002736893,0.0001015476,0.0002201687,0.0001998796,0.0002860334,0.001228292],"category_scores_gemma":[0.00007015787,0.0001264431,0.0001801717,0.0001098627,0.0001651842,0.0001760736,0.0001034619,0.0006705502,0.0002268101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793117,"about_ca_system_score_gemma":0.0002295006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002710094,"about_ca_topic_score_gemma":0.0008455362,"domain_scores_codex":[0.999941,0.000008674948,0.000004655586,0.000008640122,0.00001394778,0.00002307016],"domain_scores_gemma":[0.9999317,0.000007041918,0.00001944273,0.000003948757,0.000007635157,0.00003027936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004268611,0.0001375847,0.00009901659,0.00007474877,0.000008425748,0.00008310874,0.000009496391,0.0001114981,0.9956468,0.0001548724,0.0001144017,0.003133258],"study_design_scores_gemma":[0.0007210015,0.01060817,0.003711351,0.00002350818,0.00004894598,0.0005816775,0.00003561317,0.001259827,0.9779695,0.0001074111,0.004917497,0.00001553977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919803,0.001980052,0.003161291,0.0002226044,0.00007406017,0.0001449853,0.0006929501,0.0001630181,0.001580755],"genre_scores_gemma":[0.9918593,0.001738071,0.003164211,0.0001000785,0.00001616435,0.00008512673,0.0005797567,0.00001264591,0.002444727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228292,"threshold_uncertainty_score":0.004109085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153934400697402,"score_gpt":0.2804760363080878,"score_spread":0.2589366923011138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}