{"id":"W4392785398","doi":"10.1093/cid/ciae143","title":"Type 1 Human Immunodeficiency Virus (HIV-1) Incidence, Adherence, and Drug Resistance in Individuals Taking Daily Emtricitabine/Tenofovir Disoproxil Fumarate for HIV-1 Pre-exposure Prophylaxis: Pooled Analysis From 72 Global Studies","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"David Geffen School of Medicine, University of California, Los Angeles; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Medical Research Council; University of California, San Francisco; University of Illinois at Urbana-Champaign; Substance Abuse and Mental Health Services Administration; National Institutes of Health; Universidad Nacional Mayor de San Marcos; International AIDS Society; Universidade de São Paulo; Chinese University of Hong Kong; National Institute for Health and Care Research; Instituut voor Tropische Geneeskunde; European and Developing Countries Clinical Trials Partnership; Centers for Disease Control and Prevention; Auckland District Health Board; Rhode Island Department of Health; Wellcome Trust; London School of Hygiene and Tropical Medicine; Imperial College London; Johns Hopkins University; University of Washington; Gilead Sciences; University of Toronto; Yale University; George Washington University; Sanofi; China Medical University; Bristol-Myers Squibb; California Institute for Regenerative Medicine; Pfizer; ViiV Healthcare; Bill and Melinda Gates Foundation; University of Pennsylvania; United States Agency for International Development; Magee-Womens Research Institute; Georgetown University; Doris Duke Charitable Foundation","keywords":"Emtricitabine; Medicine; Incidence (geometry); Discontinuation; Pre-exposure prophylaxis; Internal medicine; Adverse effect; Tenofovir; Drug resistance; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Men who have sex with men; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01164962,0.00158426,0.006109097,0.004773115,0.0002907432,0.001893346,0.0008459892,0.001037331,0.001200153],"category_scores_gemma":[0.01015486,0.00106997,0.01462338,0.004910988,0.0004477028,0.0007643142,0.0009778426,0.0006159924,0.0001166414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003966805,"about_ca_system_score_gemma":0.0004294125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002403979,"about_ca_topic_score_gemma":0.003696639,"domain_scores_codex":[0.993218,0.003594923,0.001302468,0.0009897312,0.0007226237,0.0001722782],"domain_scores_gemma":[0.9894297,0.005758695,0.003385466,0.0006925612,0.0005235057,0.0002101381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.008769357,0.00004383443,0.4745053,0.01087808,0.4863528,0.0001641797,0.0001359723,0.0008856019,0.000530556,0.00005020104,0.0004318419,0.01725223],"study_design_scores_gemma":[0.001276404,0.001441706,0.4877016,0.001990604,0.5039729,0.0006297796,0.0001707205,0.00090864,0.000413055,0.0001648388,0.001270802,0.00005884273],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5059366,0.4878093,0.001179804,0.000187574,0.0001482398,0.0001781466,0.003624996,0.00005531695,0.0008800959],"genre_scores_gemma":[0.9578694,0.03891767,0.0008222129,0.0001350037,0.0001312662,0.0001753684,0.001742822,0.00001605052,0.0001902839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164962,"threshold_uncertainty_score":0.0616098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03222484406606541,"score_gpt":0.3734792385020484,"score_spread":0.341254394435983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}