{"id":"W4392785618","doi":"10.3791/65887","title":"Efficient Generation of Murine Chimeric Antigen Receptor (CAR)-T Cells","year":2024,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering","keywords":"Chimeric antigen receptor; Immune system; Context (archaeology); T cell; Cancer research; Antigen; Tumor microenvironment; Immunology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006633347,0.0004660297,0.0003531149,0.0006907969,0.0002877882,0.0005984565,0.0004228447,0.0005309124,0.002426698],"category_scores_gemma":[0.0003748382,0.0002536589,0.0003278505,0.0004175221,0.0002471209,0.0003272981,0.0004964733,0.001154458,0.001345465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424324,"about_ca_system_score_gemma":0.0005397003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003517083,"about_ca_topic_score_gemma":0.0004201108,"domain_scores_codex":[0.9995244,0.0000823619,0.00006336317,0.0001063959,0.0001246665,0.00009893293],"domain_scores_gemma":[0.999819,0.00004042709,0.00003425885,0.00003721757,0.00003191331,0.0000372849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211701,0.0000817144,0.0001597987,0.00007113886,0.000008127354,0.00008383102,0.00006906361,0.0004132494,0.9917571,0.00162217,0.0004860087,0.005126528],"study_design_scores_gemma":[0.00004187094,0.0002540855,0.0002828738,0.000006441927,0.00001784041,0.0002318156,0.00001678441,0.001350923,0.9863777,0.0001050785,0.01130861,0.000005963528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6979686,0.003521242,0.2772925,0.0004016098,0.0003322153,0.002437024,0.005262707,0.001824913,0.01095908],"genre_scores_gemma":[0.9068878,0.002688692,0.07339971,0.0001638604,0.00006529102,0.001525325,0.004266478,0.0003072347,0.01069564],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002426698,"threshold_uncertainty_score":0.008118093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06399087211917413,"score_gpt":0.4626877866837386,"score_spread":0.3986969145645644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}