{"id":"W4392793206","doi":"10.1139/bcb-2023-0339","title":"Granulocyte pro-myeloperoxidase is redundantly processed by proprotein convertase furin and PC7 in HL-60 cells","year":2024,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache; Oncolytics Biotech (Canada)","funders":"","keywords":"Furin; Proprotein Convertases; Proprotein convertase; Myeloperoxidase; Chemistry; Cell biology; Endoplasmic reticulum; Gene knockdown; Biochemistry; Biology; Molecular biology; Enzyme; Immunology; Apoptosis; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196414,0.0002166011,0.0002132311,0.0001316005,0.0001239421,0.0003365324,0.0001493832,0.0002065386,0.000567917],"category_scores_gemma":[0.00007106418,0.0001091212,0.0001970861,0.0001138281,0.0001835748,0.0001811994,0.0001873374,0.0004701653,0.0003594028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342227,"about_ca_system_score_gemma":0.000218814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007211603,"about_ca_topic_score_gemma":0.0007025265,"domain_scores_codex":[0.9997873,0.00002746812,0.00002535468,0.00003776834,0.00007582817,0.00004627571],"domain_scores_gemma":[0.9999244,0.000009119407,0.00001778135,0.00001637494,0.00001210242,0.00002021025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004239449,0.000009255786,0.00007378677,0.0000112591,0.000001426936,0.00002503838,0.000006440804,0.00001207128,0.999385,0.00004810995,0.000011374,0.00037381],"study_design_scores_gemma":[0.000008104072,0.00009455741,0.001893736,0.000002411591,0.000007778203,0.0001058246,0.00001785166,0.0005070767,0.996047,0.00002205934,0.001292174,0.000001404435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936424,0.001246764,0.003444658,0.00008808346,0.00003352463,0.00002591747,0.0003366157,0.00005882343,0.001123089],"genre_scores_gemma":[0.9939613,0.0005561167,0.001760521,0.00004552661,0.000007784793,0.00003650919,0.0006371454,0.00001333964,0.002981803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007211603,"threshold_uncertainty_score":0.001899838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007118137422490931,"score_gpt":0.2163531492078595,"score_spread":0.2092350117853685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}