{"id":"W4392797709","doi":"10.1016/j.ijrobp.2024.01.018","title":"Final Analysis of the Phase 4 KEYNOTE-B10 Study: First-Line (1L) Pembrolizumab (pembro) + Carboplatin (carbo) + Paclitaxel (pacli) for Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston General Hospital; Princess Margaret Cancer Centre; Dr. H. Bliss Murphy Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Carboplatin; Pembrolizumab; Oncology; Head and neck squamous-cell carcinoma; Paclitaxel; Internal medicine; Head and neck; Basal cell; Head and neck cancer; Chemotherapy; Cancer; Surgery; Immunotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009514525,0.001952075,0.003460053,0.00052046,0.0008451061,0.002235401,0.001838828,0.00231469,0.007766182],"category_scores_gemma":[0.003987412,0.001031413,0.004665455,0.0006953136,0.0009910861,0.0014298,0.0007275458,0.004201599,0.002789211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002648685,"about_ca_system_score_gemma":0.004833055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003112942,"about_ca_topic_score_gemma":0.008244967,"domain_scores_codex":[0.997626,0.001277265,0.00009466812,0.0002851522,0.0002706614,0.0004461929],"domain_scores_gemma":[0.9974739,0.000463403,0.0004099044,0.0003164857,0.0003796282,0.0009566395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8333519,0.01253762,0.008250226,0.001842949,0.009443428,0.0003342371,0.000317501,0.00477966,0.02708153,0.0006352973,0.02742882,0.07399672],"study_design_scores_gemma":[0.7134039,0.2016352,0.03975623,0.0002704954,0.007388505,0.0004849679,0.0001725812,0.001985481,0.005990859,0.001007202,0.02778979,0.0001148536],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8860893,0.009966179,0.005596172,0.005008077,0.001396845,0.02177785,0.05454205,0.0009097787,0.01471375],"genre_scores_gemma":[0.8725819,0.004248331,0.01194247,0.008125096,0.0004546795,0.01544116,0.07054804,0.0004562249,0.01620204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009514525,"threshold_uncertainty_score":0.05031824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066120505676308,"score_gpt":0.3823147646209947,"score_spread":0.3316535595642316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}