{"id":"W4392800123","doi":"10.1038/s41420-024-01910-x","title":"MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Horizon 2020 Framework Programme; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Cancer-Associated Fibroblasts; Tumor microenvironment; Breast cancer; Cancer research; Stromal cell; Cancer cell; Cancer; Reprogramming; Gene knockdown; Warburg effect; Tumor progression; Biology; Medicine; Internal medicine; Cell; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002317482,0.0003542729,0.000382555,0.00007533246,0.00008176374,0.000152948,0.0002463252,0.0002154439,0.000153413],"category_scores_gemma":[0.00001399137,0.000331855,0.0002396261,0.0002183537,0.0001086844,0.00003995268,0.0001819811,0.0002593736,0.00003604842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009461334,"about_ca_system_score_gemma":0.0002174715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583574,"about_ca_topic_score_gemma":0.0002094663,"domain_scores_codex":[0.9976379,0.00008972477,0.0003887299,0.001036595,0.0002202664,0.0006268172],"domain_scores_gemma":[0.9991083,0.00001783068,0.00007615999,0.0006088206,0.00002499166,0.0001639548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009705194,0.0002727276,0.01440654,0.0001492518,0.0001160892,0.000009118326,0.0001996982,0.0001427839,0.9448617,0.00001297667,0.03653841,0.003193716],"study_design_scores_gemma":[0.0006410156,0.00003206813,0.009252945,0.00004691301,0.0001019451,0.00001333315,0.00006864686,0.0001426184,0.2422443,0.0000242463,0.7470241,0.0004077856],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8593878,0.1367868,0.0002887362,0.0004217002,0.001180736,0.0003932055,0.001257854,0.00003158899,0.0002515377],"genre_scores_gemma":[0.9624882,0.02818016,0.000238954,0.0007637162,0.001006379,0.0002959524,0.0006611585,0.00008041376,0.006285092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7104858,"threshold_uncertainty_score":0.9999133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006607172015654205,"score_gpt":0.2369317413563965,"score_spread":0.2303245693407423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}