{"id":"W4392806017","doi":"10.3389/fnins.2024.1274174","title":"Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection","year":2024,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norges Forskningsråd; Helse Midt-Norge; Faculty of Medicine and Health, University of Sydney; Trond Mohn stiftelse","keywords":"Enhancer; Promoter; Biology; Transgene; Cell type; Gene; Computational biology; Hippocampal formation; Neural cell; Gene expression; Cell biology; Genetics; Neuroscience; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003857092,0.0006951122,0.0005673502,0.0006796822,0.000255193,0.0006267805,0.0008434685,0.0006852784,0.002092215],"category_scores_gemma":[0.0003099322,0.0004384328,0.0004344004,0.0002782139,0.0006114997,0.0005104608,0.0006536162,0.001934266,0.001191206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263711,"about_ca_system_score_gemma":0.0005314942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005834092,"about_ca_topic_score_gemma":0.001109043,"domain_scores_codex":[0.9996107,0.00002608117,0.00003997338,0.0001279153,0.00011096,0.00008442591],"domain_scores_gemma":[0.9997305,0.00005558,0.00007161136,0.00004435689,0.00003266037,0.00006521046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000392649,0.00003309569,0.00009987754,0.00005465551,0.000005662464,0.0000484848,0.00004544573,0.00008332547,0.9945232,0.00141354,0.00009084972,0.003562636],"study_design_scores_gemma":[0.00002599944,0.0001871067,0.0006141743,0.00001916346,0.00002028296,0.0001967221,0.00002173501,0.001054406,0.9877461,0.0002088905,0.009897241,0.0000080796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6381735,0.002033331,0.3421246,0.0004498492,0.0004537647,0.001223753,0.003018434,0.002508549,0.01001423],"genre_scores_gemma":[0.7483731,0.003112794,0.2177663,0.0002941452,0.00008183939,0.0009559743,0.003411624,0.001001579,0.02500272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002092215,"threshold_uncertainty_score":0.006999135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181058685979132,"score_gpt":0.2708563087743512,"score_spread":0.2490457219145599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}