{"id":"W4392808556","doi":"10.1038/s42003-024-05902-6","title":"Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"Aspergillus fumigatus; Biology; Genetics; Genome; Azole; Population; Pathogenic fungus; Mutant; Fungus; Genetic diversity; Microbiology; Gene; Antifungal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006403404,0.0001029004,0.0003153553,0.00007268005,0.0002387403,0.000004286937,0.001063095,0.0001010827,0.00007576102],"category_scores_gemma":[0.0001771958,0.00006433155,0.0001818892,0.0004014925,0.001044303,0.00002150028,0.001100887,0.0003192265,0.0000140202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430538,"about_ca_system_score_gemma":0.0001665049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002043368,"about_ca_topic_score_gemma":0.002844872,"domain_scores_codex":[0.9986931,0.0004269781,0.0004250386,0.0002014524,0.00007945602,0.0001739628],"domain_scores_gemma":[0.9969343,0.0005038683,0.0001233173,0.002312171,0.00009465362,0.00003168045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001019558,0.00009812866,0.7606333,0.0001204108,0.00008007837,7.419362e-7,0.001131275,0.000002748694,0.2219606,0.014,0.0004341229,0.001436555],"study_design_scores_gemma":[0.0002215876,0.00003909809,0.9919432,0.00009884605,0.00007941954,0.000003446066,0.0005356969,0.0001382401,0.0004652568,0.001543616,0.004870993,0.00006055082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751253,0.01758509,0.00001676479,0.00361481,0.00007249209,0.0003836751,0.0001514219,0.00001666076,0.003033812],"genre_scores_gemma":[0.9968737,0.002018258,0.0003672778,0.0001861359,0.00001600168,0.0000123628,0.00003989635,0.000008778409,0.0004775425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2313099,"threshold_uncertainty_score":0.3847778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05845661154723882,"score_gpt":0.3118142936937228,"score_spread":0.253357682146484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}