{"id":"W4392810524","doi":"10.3390/ph17030371","title":"The Effect of Heparin and Other Exogenous Glycosaminoglycans (GAGs) in Reducing IL-1β-Induced Pro-Inflammatory Cytokine IL-8 and IL-6 mRNA Expression and the Potential Role for Reducing Inflammation","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Max Rady College of Medicine, University of Manitoba; Public Health Agency; Public Health Agency of Canada","keywords":"Glycosaminoglycan; Chondroitin; Dermatan sulfate; Heparin; Inflammation; Chemistry; Cytokine; Messenger RNA; Cell biology; Proinflammatory cytokine; Molecular biology; Receptor; Cell adhesion; Chondroitin sulfate; Cell; Biology; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126843,0.0003402271,0.0002446183,0.0001283829,0.0000953507,0.0001809439,0.0001418495,0.0002549466,0.001042753],"category_scores_gemma":[0.00009856844,0.00008060702,0.0002908694,0.0001089923,0.0001975028,0.0001753325,0.0001059307,0.0004331134,0.0001324724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112939,"about_ca_system_score_gemma":0.0002340689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006580433,"about_ca_topic_score_gemma":0.001065141,"domain_scores_codex":[0.9999135,0.00002100921,0.000009316656,0.00001299029,0.00001956293,0.00002367282],"domain_scores_gemma":[0.999953,0.000007702723,0.00001036933,0.000004666309,0.0000082895,0.00001587145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001035651,0.0002566819,0.0002418498,0.0002262608,0.00001848471,0.00005943147,0.00001873504,0.00007335413,0.9908842,0.00009747518,0.0000653052,0.007022522],"study_design_scores_gemma":[0.0001438781,0.004362302,0.005415683,0.00002090405,0.00006468616,0.0001683807,0.00004233436,0.000714939,0.9852803,0.00006039622,0.003716524,0.000009600264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859644,0.0110269,0.001444799,0.0001672398,0.000105178,0.00005954537,0.0001699185,0.00003114985,0.001030769],"genre_scores_gemma":[0.9849163,0.008113579,0.003805579,0.0001510292,0.00005391596,0.00005907995,0.0003415995,0.00001140613,0.002547433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042753,"threshold_uncertainty_score":0.003488362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740504072370139,"score_gpt":0.3226694563576019,"score_spread":0.3052644156339005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}