{"id":"W4392810524","doi":"10.3390/ph17030371","title":"The Effect of Heparin and Other Exogenous Glycosaminoglycans (GAGs) in Reducing IL-1β-Induced Pro-Inflammatory Cytokine IL-8 and IL-6 mRNA Expression and the Potential Role for Reducing Inflammation","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Max Rady College of Medicine, University of Manitoba; Public Health Agency; Public Health Agency of Canada","keywords":"Glycosaminoglycan; Chondroitin; Dermatan sulfate; Heparin; Inflammation; Chemistry; Cytokine; Messenger RNA; Cell biology; Proinflammatory cytokine; Molecular biology; Receptor; Cell adhesion; Chondroitin sulfate; Cell; Biology; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002087095,0.0002574765,0.0003031876,0.00009529395,0.0002822053,0.0001568146,0.0001963749,0.0001683472,0.000004433811],"category_scores_gemma":[0.0003086757,0.0001569821,0.0000821418,0.0001254731,0.000398343,0.00002253687,0.0002636226,0.0002946374,7.696031e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002659036,"about_ca_system_score_gemma":0.00008686063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001160138,"about_ca_topic_score_gemma":0.00003455727,"domain_scores_codex":[0.997928,0.0004103851,0.0004351126,0.0005301351,0.0002427955,0.0004535945],"domain_scores_gemma":[0.999047,0.0003667689,0.00009058558,0.0003069225,0.00005697269,0.0001317744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001914337,0.00001311365,0.0003411597,0.0003735858,0.00008048392,0.000007271227,0.0003725013,0.00004392104,0.910633,0.0001758481,0.00003748351,0.08600735],"study_design_scores_gemma":[0.002836827,0.0004014262,0.0003321866,0.0001924191,0.00007943335,0.00006613095,0.000116474,0.01719854,0.9646199,0.0002386197,0.01371905,0.0001990115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899155,0.00684586,0.0003349362,0.0006670081,0.0001179735,0.00187997,0.00008983105,0.00001817579,0.0001307373],"genre_scores_gemma":[0.9972968,0.001604345,0.0001323653,0.00003367192,0.0003186566,0.00044033,0.00001723444,0.0000421844,0.000114399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08580834,"threshold_uncertainty_score":0.6401546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740504072370139,"score_gpt":0.3226694563576019,"score_spread":0.3052644156339005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}