{"id":"W4392824195","doi":"10.1016/j.ijrobp.2024.01.095","title":"Lenvatinib ± Pembrolizumab Versus Chemotherapy for Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) That Progressed after Platinum and Immunotherapy: The Phase 2 LEAP-009 Study","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Pembrolizumab; Lenvatinib; Oncology; Immunotherapy; Head and neck squamous-cell carcinoma; Internal medicine; Chemotherapy; Head and neck cancer; Head and neck; Radiation therapy; Cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001009375,0.00084409,0.001738424,0.0003515566,0.000300604,0.001029032,0.0008164323,0.001015353,0.00359221],"category_scores_gemma":[0.0007963671,0.0004407208,0.001354738,0.0003239274,0.0005635953,0.001095152,0.0003262283,0.003005489,0.0007658996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001140199,"about_ca_system_score_gemma":0.001033062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001457901,"about_ca_topic_score_gemma":0.004887286,"domain_scores_codex":[0.9996421,0.0001606028,0.00001817111,0.00006977934,0.00003126257,0.00007818955],"domain_scores_gemma":[0.9995901,0.00009700876,0.00008050411,0.00003317699,0.00002167739,0.0001774754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8601208,0.01811136,0.002716443,0.0008426486,0.002103542,0.0001118572,0.0001284361,0.002449916,0.0103528,0.0002963653,0.002382239,0.1003837],"study_design_scores_gemma":[0.6014299,0.3758895,0.01254975,0.0001034135,0.001485434,0.0001949114,0.0001239416,0.001880176,0.002535445,0.0004193441,0.003353036,0.00003514103],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928249,0.002997938,0.000173868,0.0004320124,0.0002303377,0.0005948514,0.0005846123,0.00005149661,0.002109908],"genre_scores_gemma":[0.9907335,0.002416275,0.0005748793,0.000864107,0.0001589617,0.0007237481,0.0009550505,0.00002014706,0.003553275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00359221,"threshold_uncertainty_score":0.01201719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572312827593933,"score_gpt":0.3679507956196816,"score_spread":0.3322276673437423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}