{"id":"W4392841311","doi":"10.2139/ssrn.4709935","title":"Design, Synthesis and Biological Evaluation of New 2,6-Difluorinated Phenyl 4-(2-Oxoimidazolidin-1-Yl)Benzenesulfonates as New Antimicrotubule Agents","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Combinatorial chemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003590597,0.0004506619,0.0003310491,0.0002560226,0.0001501197,0.0003041411,0.0003593591,0.0003539638,0.001127181],"category_scores_gemma":[0.0001769561,0.0001750672,0.0002070108,0.000172957,0.0002098675,0.0001934462,0.0001977955,0.0002858941,0.0005123653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004100347,"about_ca_system_score_gemma":0.0003900223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005696915,"about_ca_topic_score_gemma":0.001170156,"domain_scores_codex":[0.9998441,0.00004319482,0.0000145587,0.00002354968,0.00003517788,0.00003944852],"domain_scores_gemma":[0.9999167,0.000009407721,0.00002414289,0.000006559498,0.00002104375,0.00002208801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773551,0.00009003957,0.0001244199,0.0001230134,0.000009409569,0.00008595242,0.00004176982,0.001019657,0.9899803,0.0006034203,0.0001681551,0.007476461],"study_design_scores_gemma":[0.0001053493,0.00165488,0.000583962,0.00001094628,0.00002372019,0.0001228694,0.00001967606,0.001022312,0.9876969,0.00006975489,0.008678281,0.00001130299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661534,0.008987196,0.01673019,0.0003046372,0.0001168173,0.0003033882,0.0007141609,0.0002415815,0.006448588],"genre_scores_gemma":[0.9756684,0.005221738,0.01235859,0.0001177729,0.00002444356,0.0001591313,0.0007207552,0.00003199168,0.005697162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127181,"threshold_uncertainty_score":0.003770828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07973861793722038,"score_gpt":0.308798127817885,"score_spread":0.2290595098806646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}