{"id":"W4392851800","doi":"10.1002/jbm.a.37705","title":"Influence of ionizable lipid tail length on lipid nanoparticle delivery of <scp>mRNA</scp> of varying length","year":2024,"lang":"en","type":"article","venue":"Journal of Biomedical Materials Research Part A","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Heart, Lung, and Blood Institute; Vagelos Institute for Energy Science and Technology, University of Pennsylvania; Division of Chemistry; Canadian Aeronautics and Space Institute; Division of Chemical, Bioengineering, Environmental, and Transport Systems; University of Pennsylvania; National Science Foundation; National Institutes of Health; American Cancer Society","keywords":"Messenger RNA; Chemistry; RNA; Transfection; Biophysics; Molecular biology; Cell biology; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002442924,0.0003452167,0.0001516475,0.0001221519,0.000089933,0.0003280747,0.0001177885,0.0002022254,0.0006654758],"category_scores_gemma":[0.0003195535,0.0001304481,0.0001508542,0.0001419753,0.0001699503,0.0002498202,0.0001424266,0.0002510355,0.000223163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002287896,"about_ca_system_score_gemma":0.0001542329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004778092,"about_ca_topic_score_gemma":0.0006669788,"domain_scores_codex":[0.9998738,0.00002756418,0.00001595232,0.00002918318,0.00002571152,0.00002773547],"domain_scores_gemma":[0.9997851,0.00008753633,0.00006122622,0.000008679363,0.00002975681,0.00002760477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002418912,0.00003468259,0.000153773,0.00003809224,0.000007569665,0.00002502051,0.00001965719,0.0004406546,0.9973743,0.00003396509,0.00002231257,0.0016082],"study_design_scores_gemma":[0.000007028606,0.0002519145,0.0005517679,0.000003131469,0.0000116114,0.0000133953,0.000007421988,0.0007704759,0.9980757,0.000007549602,0.0002949534,0.000004936859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975191,0.0003427666,0.001122294,0.00001987626,0.000006697437,0.00001798253,0.00007727549,0.00002570943,0.0008683066],"genre_scores_gemma":[0.9967592,0.0004035273,0.002109228,0.00003744183,0.000003430739,0.00002961929,0.00009852611,0.00002287429,0.0005360998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006654758,"threshold_uncertainty_score":0.002226293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0327527465716262,"score_gpt":0.3244698177489168,"score_spread":0.2917170711772906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}