{"id":"W4392853670","doi":"10.1136/lupus-2024-el.41","title":"O32 Impact of patient baseline characteristics on SLE Responder Index-4 (SRI[4]) responses to deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor in the phase 2 PAISLEY trial in systemic lupus erythematosus","year":2024,"lang":"en","type":"article","venue":"Oral Presentations","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"EMD Serono; Genentech; Stockholms Läns Landsting; Celgene; Biogen; Hjärt-Lungfonden; Gilead Sciences; Servier; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Allosteric regulation; Index (typography); Tyrosine-kinase inhibitor; Kinase; Class (philosophy); Medicine; Pharmacology; Chemistry; Internal medicine; Computer science; Receptor; Biochemistry; Cancer; World Wide Web; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002041211,0.0004127846,0.0009002593,0.002022645,0.00008133944,0.0001400696,0.000304798,0.0001981789,0.0001293774],"category_scores_gemma":[0.00299013,0.0002940604,0.0002358366,0.003130832,0.0001127236,0.0002403999,0.0001154381,0.0006828316,0.00006665619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007973984,"about_ca_system_score_gemma":0.0009172632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000972578,"about_ca_topic_score_gemma":0.0009347255,"domain_scores_codex":[0.9944642,0.001611278,0.001508698,0.0006747023,0.001051306,0.0006898756],"domain_scores_gemma":[0.9959108,0.002621071,0.0002039879,0.0007386945,0.0002965378,0.0002289571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2948923,0.008850152,0.5680112,0.003119061,0.0004317373,0.004766968,0.04374199,0.0006449137,0.02935014,0.0002603306,0.04346192,0.0024694],"study_design_scores_gemma":[0.5403907,0.06624739,0.12124,0.05139349,0.001133263,0.03373139,0.05989926,0.09355352,0.01415236,0.0007286066,0.01292225,0.004607723],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915236,0.0003693523,0.00007477764,0.001426363,0.000724979,0.00523522,0.0003785559,0.00006369172,0.0002034668],"genre_scores_gemma":[0.9976336,0.00005641715,0.0001084592,0.000125852,0.0001856682,0.0009341339,0.0001702372,0.00007255446,0.0007130399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4467712,"threshold_uncertainty_score":0.9999511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04277243170061878,"score_gpt":0.3778026036863363,"score_spread":0.3350301719857175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}