{"id":"W4392853670","doi":"10.1136/lupus-2024-el.41","title":"O32 Impact of patient baseline characteristics on SLE Responder Index-4 (SRI[4]) responses to deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor in the phase 2 PAISLEY trial in systemic lupus erythematosus","year":2024,"lang":"en","type":"article","venue":"Oral Presentations","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"EMD Serono; Genentech; Stockholms Läns Landsting; Celgene; Biogen; Hjärt-Lungfonden; Gilead Sciences; Servier; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Allosteric regulation; Index (typography); Tyrosine-kinase inhibitor; Kinase; Class (philosophy); Medicine; Pharmacology; Chemistry; Internal medicine; Computer science; Receptor; Biochemistry; Cancer; World Wide Web; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00316492,0.0003630188,0.0009449719,0.0001698457,0.000247752,0.0005897417,0.0002856236,0.0008005213,0.008448048],"category_scores_gemma":[0.002667856,0.0001589495,0.001963142,0.0002726767,0.0003292189,0.0006687422,0.0002409124,0.001056761,0.0006302942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004526044,"about_ca_system_score_gemma":0.0006567204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005317552,"about_ca_topic_score_gemma":0.001376348,"domain_scores_codex":[0.9982053,0.001024527,0.0001288594,0.0002242954,0.0001721135,0.0002449439],"domain_scores_gemma":[0.998046,0.001096411,0.000362678,0.0001144548,0.00006282637,0.0003176227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8649524,0.005463819,0.05319893,0.0004127224,0.002198185,0.0001065863,0.00009731822,0.001441769,0.007969295,0.0002379026,0.003417384,0.06050367],"study_design_scores_gemma":[0.1782955,0.3504772,0.4444265,0.0001384339,0.003692892,0.0003859305,0.0001660261,0.005116698,0.005955684,0.0009745911,0.01024141,0.000129163],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946762,0.001158613,0.0002532593,0.0002369841,0.00008314428,0.0002927427,0.001191535,0.00002158482,0.002085818],"genre_scores_gemma":[0.9974526,0.000128948,0.0002435277,0.000232271,0.00006866513,0.0002858762,0.0007461284,0.000007643463,0.0008344759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008448048,"threshold_uncertainty_score":0.02826148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04277243170061878,"score_gpt":0.3778026036863363,"score_spread":0.3350301719857175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}