{"id":"W4392857396","doi":"10.1016/j.neurobiolaging.2024.03.003","title":"Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging","keywords":"Nucleus basalis; Neuroscience; Alzheimer's disease; Entorhinal cortex; Psychology; Hippocampus; Degeneration (medical); Cholinergic; Disease; Medicine; Pathology; Cholinergic neuron","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005846142,0.0002733589,0.0002904789,0.0006298036,0.0002272985,0.0005434072,0.0002542058,0.0003011318,0.001047864],"category_scores_gemma":[0.001235959,0.0001792987,0.0002018954,0.0002956751,0.0003617526,0.0005257129,0.0004635878,0.000289052,0.000187329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016128,"about_ca_system_score_gemma":0.000245516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005349707,"about_ca_topic_score_gemma":0.013008,"domain_scores_codex":[0.9998719,0.00002516309,0.00001014732,0.0000472817,0.00002265122,0.00002291255],"domain_scores_gemma":[0.9997157,0.00003768038,0.0001347869,0.00004373502,0.00004084732,0.00002714839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003364668,0.0001308092,0.8683862,0.0001696223,0.0002977513,0.0004613633,0.001346867,0.0009640382,0.09096885,0.0004825704,0.0005248037,0.03290235],"study_design_scores_gemma":[0.00001103197,0.0001569798,0.9928315,0.00002057238,0.00003771231,0.0004323674,0.0002423928,0.000783843,0.004668144,0.0004016824,0.0004059282,0.000007805037],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971421,0.0004482928,0.001551275,0.0000296175,0.000008010017,0.00001585999,0.0003201495,0.00001848105,0.0004662083],"genre_scores_gemma":[0.9975961,0.0001685166,0.001481259,0.00001204216,0.000003246173,0.00002214922,0.0002726894,0.000006812631,0.0004371365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005349707,"threshold_uncertainty_score":0.0106371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04182678828142786,"score_gpt":0.3535495542436302,"score_spread":0.3117227659622023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}