{"id":"W4392859966","doi":"10.1016/j.lungcan.2024.107535","title":"A pragmatic guide for management of adverse events associated with lorlatinib","year":2024,"lang":"en","type":"review","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Pfizer","keywords":"Medicine; Adverse effect; Clinical trial; Anaplastic lymphoma kinase; Concomitant; Tyrosine-kinase inhibitor; Intensive care medicine; Oncology; Internal medicine; Lung cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009800148,0.0003064197,0.001122887,0.0001278458,0.00003439592,0.00000316487,0.0000812529,0.0001110421,0.0001132966],"category_scores_gemma":[0.0000129693,0.0001886577,0.0003772709,0.0003546939,0.00002229996,0.00003182615,0.00003041387,0.0001229149,0.00001051962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001023546,"about_ca_system_score_gemma":0.0006761382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004430204,"about_ca_topic_score_gemma":0.00004802627,"domain_scores_codex":[0.9986625,0.00002321156,0.0004986224,0.0003338503,0.0002633932,0.0002184614],"domain_scores_gemma":[0.9991162,0.0000610642,0.0003560379,0.000286566,0.0001086516,0.0000714121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006660543,0.000359321,0.0001500871,0.3737406,0.04254289,0.0001262551,0.000351934,0.00001968792,9.705187e-8,0.0007453219,0.03426479,0.5476325],"study_design_scores_gemma":[0.001368406,0.0001272325,0.00004705803,0.1571524,0.06786069,0.000006172059,0.00003308222,0.00004522232,1.676656e-7,0.00002142894,0.7731697,0.0001684175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006093679,0.987536,0.0001167754,0.00006814428,0.0003715428,0.004597798,0.0007091852,0.00005490954,0.006539574],"genre_scores_gemma":[0.000020867,0.949828,0.001292406,0.00004215591,0.00009156249,0.003920596,0.000771413,0.00009468507,0.04393832],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7389049,"threshold_uncertainty_score":0.7693238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02798082182953378,"score_gpt":0.4324065033874051,"score_spread":0.4044256815578713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}