{"id":"W4392876740","doi":"10.1101/2024.03.15.24304290","title":"Genetic variation in <i>HIF1A</i> is associated with smoldering inflammation and disease progression in Multiple Sclerosis","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"European Commission","keywords":"Multiple sclerosis; Single-nucleotide polymorphism; Inflammation; HIF1A; Disease; Allele; Odds ratio; Biology; Medicine; Immunology; Gene; Internal medicine; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006782693,0.0004582565,0.0003814739,0.0007898528,0.0002619187,0.0004232597,0.0003240559,0.0004523598,0.001930138],"category_scores_gemma":[0.001243289,0.0001759981,0.000618614,0.000879282,0.0003230119,0.0001093185,0.0003125577,0.0003747258,0.0002040389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995953,"about_ca_system_score_gemma":0.0001661816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003680925,"about_ca_topic_score_gemma":0.002799623,"domain_scores_codex":[0.9994759,0.0001930507,0.00003610542,0.0001993091,0.00005396119,0.00004173537],"domain_scores_gemma":[0.9985198,0.000418051,0.0007115388,0.0001164375,0.0000855642,0.0001485657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001449788,0.00003534975,0.983303,0.00004768624,0.001036941,0.0004503542,0.0001050864,0.0004206793,0.009455975,0.00008751967,0.0002039821,0.003403671],"study_design_scores_gemma":[0.00001773305,0.00008810028,0.9982796,0.00001062623,0.0001847353,0.0003836452,0.00002087011,0.0004933227,0.00030616,0.00006301722,0.0001485022,0.000003724718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988376,0.0003466936,0.0002585197,0.00005491775,0.000006968857,0.000004478405,0.0002305659,0.00001148725,0.0002486269],"genre_scores_gemma":[0.9994475,0.0000676218,0.0001814412,0.00001592868,0.0000145566,0.000003451105,0.0001577607,0.000003180271,0.0001084823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003680925,"threshold_uncertainty_score":0.007318974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05763309653102659,"score_gpt":0.2976187969386854,"score_spread":0.2399857004076588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}