{"id":"W4392878999","doi":"10.1038/s41419-024-06591-z","title":"Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Natural Sciences and Engineering Research Council of Canada; Comisión Nacional de Investigación Científica y Tecnológica; Dr. Rolf M. Schwiete Stiftung; Canadian Institutes of Health Research; Universidad de Concepción; Consejo Nacional de Innovación, Ciencia y Tecnología; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Biology; Kinase; Cell biology; Programmed cell death; Casein kinase 2; Phosphorylation; Protein kinase A; Biochemistry; Cancer research; Cyclin-dependent kinase 2; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008851943,0.0003973788,0.0002370372,0.0002874964,0.0001481984,0.0001924837,0.0001281428,0.0001777592,0.001643855],"category_scores_gemma":[0.00008678527,0.0001560073,0.000247675,0.0002300364,0.0001465052,0.00008777754,0.0001727973,0.0004960414,0.0005073766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376107,"about_ca_system_score_gemma":0.0002845502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406287,"about_ca_topic_score_gemma":0.001985812,"domain_scores_codex":[0.9999024,0.00001247386,0.000008406265,0.00001565487,0.00002717766,0.00003384663],"domain_scores_gemma":[0.9999168,0.000007921673,0.0000205549,0.000009904075,0.000007665182,0.00003728435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001609195,0.00002809049,0.0001658243,0.00003173967,0.000005993178,0.00006737986,0.00000600545,0.0000447821,0.9988213,0.00002907331,0.0001216882,0.0005172428],"study_design_scores_gemma":[0.00006676058,0.0003802099,0.009670552,0.000005401965,0.00001628936,0.0003862415,0.00002797932,0.002247209,0.9840968,0.00003784822,0.003059304,0.00000543725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940373,0.001807649,0.001132645,0.0002006532,0.00006548996,0.00002839362,0.0006180493,0.0002042875,0.001905567],"genre_scores_gemma":[0.9939994,0.0006684701,0.0008451491,0.0001111548,0.00001410853,0.0000439574,0.001333633,0.0000172341,0.002966922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643855,"threshold_uncertainty_score":0.005499303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006181277190157434,"score_gpt":0.2291769863421469,"score_spread":0.2229957091519895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}