{"id":"W4392878999","doi":"10.1038/s41419-024-06591-z","title":"Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Natural Sciences and Engineering Research Council of Canada; Comisión Nacional de Investigación Científica y Tecnológica; Dr. Rolf M. Schwiete Stiftung; Canadian Institutes of Health Research; Universidad de Concepción; Consejo Nacional de Innovación, Ciencia y Tecnología; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Biology; Kinase; Cell biology; Programmed cell death; Casein kinase 2; Phosphorylation; Protein kinase A; Biochemistry; Cancer research; Cyclin-dependent kinase 2; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004489675,0.00009616876,0.00005912804,0.00002175982,0.00005535682,0.00005270281,0.00004554437,0.00004843361,0.00001496101],"category_scores_gemma":[0.000007546102,0.00006192564,0.00002665273,0.00005302159,0.00005332538,0.000005169278,0.0000336706,0.00007259002,0.000002079945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009611785,"about_ca_system_score_gemma":0.0001101883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852871,"about_ca_topic_score_gemma":0.00003541134,"domain_scores_codex":[0.9994897,0.00002440568,0.00008038925,0.000228184,0.00004931469,0.000128003],"domain_scores_gemma":[0.9997222,0.00001169622,0.00001647294,0.00008541242,0.00001095261,0.0001532311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002990373,0.00005058294,0.002540233,0.0002529903,0.00003079703,0.0002043671,0.0001461089,0.0001399713,0.9864229,0.00008107934,0.003722221,0.006109687],"study_design_scores_gemma":[0.0006550633,0.0001086541,0.008628514,0.0001066909,0.000114623,0.000007471023,0.000171636,0.0009908183,0.9592224,0.0002773391,0.02944953,0.0002672861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252227,0.07392925,0.000003389693,0.0003269567,0.0001612512,0.0001300428,0.00005374822,0.000006596296,0.0001660747],"genre_scores_gemma":[0.9921346,0.006781173,0.000007097909,0.000277194,0.00009966669,0.00004075896,0.00004264464,0.000009505511,0.0006073269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06714807,"threshold_uncertainty_score":0.2525254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006181277190157434,"score_gpt":0.2291769863421469,"score_spread":0.2229957091519895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}