{"id":"W4392880980","doi":"10.1016/j.isci.2024.109523","title":"Cystine-cored diphenylalanine appended peptide-based self-assembled fluorescent nanostructures direct redox-responsive drug delivery","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Luminescence and Fluorescent Materials","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Board of Research in Nuclear Sciences; National Research Council Canada; Indian Council of Medical Research; Department of Biotechnology, Ministry of Science and Technology, India; SRM Institute of Science and Technology","keywords":"Glutathione; Chemistry; Drug delivery; Doxorubicin; Cancer cell; Cystine; Biophysics; Drug; Intracellular; Cysteine; Nanotechnology; Biochemistry; Materials science; Pharmacology; Cancer; Chemotherapy; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013584,0.0001951431,0.000136176,0.0000874718,0.00008172559,0.0001498663,0.0001539666,0.0002478739,0.0003841403],"category_scores_gemma":[0.00009929948,0.0001169343,0.0001396943,0.00005615031,0.0001315012,0.0001754012,0.0001557172,0.0001785995,0.0001842552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374247,"about_ca_system_score_gemma":0.0001426303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003539915,"about_ca_topic_score_gemma":0.0007619152,"domain_scores_codex":[0.9999369,0.000009455241,0.000005529176,0.00001818542,0.00001650136,0.00001349952],"domain_scores_gemma":[0.999944,0.000008462655,0.0000177593,0.000005050363,0.00001150289,0.00001333317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001598433,0.000005701155,0.00003050504,0.00001380016,0.00000196589,0.00002334604,0.000007438098,0.0001443291,0.9988932,0.00005990378,0.00001915431,0.0007847609],"study_design_scores_gemma":[0.000003468721,0.00006878474,0.0002559712,8.553944e-7,0.000003467001,0.00005130411,0.000004251766,0.001388889,0.9974639,0.00001177109,0.0007447749,0.000002577769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882111,0.0005687287,0.009703091,0.00005722283,0.00001976588,0.00002754254,0.00009023474,0.0001266965,0.001195587],"genre_scores_gemma":[0.9893681,0.0002246869,0.008510225,0.00003327903,0.000004608737,0.00001627651,0.0001163879,0.00001567726,0.001710801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003841403,"threshold_uncertainty_score":0.001722634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007583987036883726,"score_gpt":0.2356881849078191,"score_spread":0.2281041978709354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}