{"id":"W4392880980","doi":"10.1016/j.isci.2024.109523","title":"Cystine-cored diphenylalanine appended peptide-based self-assembled fluorescent nanostructures direct redox-responsive drug delivery","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Luminescence and Fluorescent Materials","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Board of Research in Nuclear Sciences; National Research Council Canada; Indian Council of Medical Research; Department of Biotechnology, Ministry of Science and Technology, India; SRM Institute of Science and Technology","keywords":"Glutathione; Chemistry; Drug delivery; Doxorubicin; Cancer cell; Cystine; Biophysics; Drug; Intracellular; Cysteine; Nanotechnology; Biochemistry; Materials science; Pharmacology; Cancer; Chemotherapy; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001393794,0.0005361516,0.00055892,0.0003405039,0.0004614867,0.001046586,0.001237996,0.0001370277,0.0007074997],"category_scores_gemma":[0.0003074256,0.000410959,0.0001879786,0.0008016807,0.0002471631,0.0008260591,0.0003239013,0.0001965306,0.001213571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000238881,"about_ca_system_score_gemma":0.0007902163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002829273,"about_ca_topic_score_gemma":0.00006851794,"domain_scores_codex":[0.9952839,0.0003140764,0.0007063301,0.001387126,0.001158719,0.001149828],"domain_scores_gemma":[0.9980536,0.0003405029,0.0001857834,0.000826402,0.0002482759,0.0003454771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000202224,0.00008939023,0.0004281408,0.0001796424,0.00001157749,0.0002799924,0.0008615039,0.00009529913,0.9876705,0.0002333691,0.009458354,0.0004899892],"study_design_scores_gemma":[0.0005146276,0.0001162362,0.002486014,0.0004220091,0.00006309026,0.00004479766,0.0001125427,0.003240714,0.9870532,0.0002592036,0.005089573,0.0005980171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911385,0.001196831,0.0001694672,0.0006980003,0.003965386,0.000679197,0.00009536635,0.001156171,0.0009011068],"genre_scores_gemma":[0.9948465,0.00005203976,0.00359286,0.0003692733,0.0004148869,0.00006860562,0.0000229678,0.00005591893,0.0005769728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004368781,"threshold_uncertainty_score":0.9999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007583987036883726,"score_gpt":0.2356881849078191,"score_spread":0.2281041978709354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}