{"id":"W4392882030","doi":"10.1016/j.jcmgh.2024.03.006","title":"Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic Hypersensitivity","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dysbiosis; Irritable bowel syndrome; Visceral pain; Dorsal root ganglion; Gut flora; Medicine; In vivo; Nociception; Pharmacology; Immunology; Spinal cord; Internal medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591969,0.0003762442,0.0004347212,0.0002348432,0.0001216591,0.000281153,0.0001735882,0.0004150908,0.00175068],"category_scores_gemma":[0.0001597856,0.000162596,0.0004565582,0.0002015336,0.0002668066,0.0001451674,0.0002148914,0.000903143,0.0002550052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389617,"about_ca_system_score_gemma":0.0001459941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002998538,"about_ca_topic_score_gemma":0.0006550652,"domain_scores_codex":[0.9997485,0.00003398937,0.00002460389,0.00005311664,0.00005221595,0.00008755307],"domain_scores_gemma":[0.9998067,0.00002179387,0.0000803879,0.00001359475,0.00002091076,0.00005680017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003852712,0.00003233059,0.0004048186,0.00005847918,0.00001116993,0.00006669227,0.000007877325,0.00001143862,0.9984599,0.000009044928,0.00001853916,0.0005344008],"study_design_scores_gemma":[0.00009223779,0.001951943,0.09232628,0.00003574431,0.00006294715,0.0006945076,0.00009445973,0.0005522684,0.9035342,0.00006513555,0.0005805712,0.000009931782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950761,0.002178184,0.001341536,0.0001003364,0.00004568437,0.00004259685,0.0004308393,0.00004279392,0.0007420254],"genre_scores_gemma":[0.9962226,0.001018974,0.001305058,0.0000908832,0.00001547503,0.0000830187,0.0003534271,0.000009838477,0.0009008294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175068,"threshold_uncertainty_score":0.005856574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007198047197094868,"score_gpt":0.2247763034735721,"score_spread":0.2175782562764772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}