{"id":"W4392882030","doi":"10.1016/j.jcmgh.2024.03.006","title":"Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic Hypersensitivity","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dysbiosis; Irritable bowel syndrome; Visceral pain; Dorsal root ganglion; Gut flora; Medicine; In vivo; Nociception; Pharmacology; Immunology; Spinal cord; Internal medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001952777,0.0001128821,0.0002733893,0.0001445045,0.0000311742,0.000005555344,0.00002503617,0.00008282837,0.000001857356],"category_scores_gemma":[0.0001370969,0.00008552579,0.0000375382,0.0001051768,0.0001990428,0.0000268767,0.00004134172,0.0001573195,1.840172e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001290524,"about_ca_system_score_gemma":0.00003939833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003476614,"about_ca_topic_score_gemma":0.0001042533,"domain_scores_codex":[0.9990232,0.0003361263,0.0001843791,0.0002346524,0.00006152756,0.0001600932],"domain_scores_gemma":[0.9996751,0.00006622104,0.00005555271,0.0001078747,0.00004652919,0.00004871598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002889032,0.0000909506,0.1970199,0.0001238611,0.00006251255,0.000209653,0.0008431886,0.000001943503,0.7986127,0.00003443067,0.000004736394,0.0001071494],"study_design_scores_gemma":[0.001905663,0.00297356,0.9766118,0.0002977249,0.0002713276,0.001136287,0.0001536624,0.002754216,0.01368932,0.0001433432,0.000003842167,0.00005923985],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945239,0.0001142124,0.001135492,0.003758053,0.00002942771,0.0004114737,0.00001109961,0.000008830585,0.000007518007],"genre_scores_gemma":[0.9993539,0.000003834232,0.0001484087,0.0004521437,0.000002082827,0.000008462725,0.000009932917,0.000008884577,0.00001227941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7849233,"threshold_uncertainty_score":0.348764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007198047197094868,"score_gpt":0.2247763034735721,"score_spread":0.2175782562764772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}