{"id":"W4392885091","doi":"10.1002/cpt.3235","title":"Combination Therapy With Guselkumab and Golimumab in Patients With Moderately to Severely Active Ulcerative Colitis: Pharmacokinetics, Immunogenicity and Drug–Drug Interactions","year":2024,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Janssen Research and Development","keywords":"Golimumab; Medicine; Immunogenicity; Combination therapy; Pharmacokinetics; Pharmacology; Internal medicine; Immunology; Antibody; Adalimumab; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001318493,0.0004286114,0.001879052,0.0003315949,0.0002078603,0.0005941438,0.0002385435,0.0003686404,0.0008998172],"category_scores_gemma":[0.001276191,0.000266176,0.001433166,0.0004118555,0.0002217035,0.0005020907,0.0003150534,0.0009612637,0.0002035605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004326428,"about_ca_system_score_gemma":0.0004073734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002483522,"about_ca_topic_score_gemma":0.0007730114,"domain_scores_codex":[0.9991627,0.000452549,0.00006544773,0.00009654089,0.0001607444,0.00006204154],"domain_scores_gemma":[0.9994937,0.0001893889,0.0001814815,0.00003020186,0.00003004749,0.00007518922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1562548,0.005796634,0.1272847,0.003224716,0.009989624,0.001338432,0.0005254935,0.01519588,0.08335472,0.0004614008,0.001769451,0.5948042],"study_design_scores_gemma":[0.02521393,0.3773151,0.4817568,0.0005398394,0.01140659,0.00447811,0.0004623209,0.04745723,0.02677998,0.001488166,0.02291576,0.0001860941],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773119,0.01945868,0.001764816,0.0003354963,0.00004410772,0.0001363883,0.0001232987,0.0000481038,0.0007772123],"genre_scores_gemma":[0.9959028,0.002151282,0.001339643,0.0001395188,0.00003167392,0.00007650866,0.0001075044,0.000005325604,0.0002457288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879052,"threshold_uncertainty_score":0.006972969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198500496216657,"score_gpt":0.3376945499188583,"score_spread":0.3178445002971926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}