{"id":"W4392886135","doi":"10.1101/2024.03.15.24304164","title":"CSF proteomic profiling with amyloid/tau positivity identifies distinctive sex-different alteration of multiple proteins involved in Alzheimer’s disease","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Hope Center for Neurological Disorders; Alzheimer's Association","keywords":"Biology; FYN; Internal medicine; Medicine; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004132135,0.0003404219,0.0002582747,0.0008745231,0.0002269955,0.000462037,0.0001092061,0.0002836388,0.0007558527],"category_scores_gemma":[0.0006085488,0.0001293889,0.0003299837,0.0004073781,0.0002025429,0.0001566819,0.0002194427,0.0001662942,0.000196129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453601,"about_ca_system_score_gemma":0.0001148801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006870447,"about_ca_topic_score_gemma":0.001052974,"domain_scores_codex":[0.9998007,0.00003106538,0.00002269811,0.00006207015,0.00005277937,0.00003071945],"domain_scores_gemma":[0.9997179,0.0000421344,0.0001366374,0.00002276556,0.00005242806,0.00002804044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001531249,0.00007316846,0.7717541,0.0001086761,0.0003262899,0.0008520947,0.0002185987,0.0001876619,0.1944556,0.00008963369,0.0004692881,0.02993361],"study_design_scores_gemma":[0.00001344,0.0002736889,0.9728584,0.00001323269,0.000114338,0.002443988,0.0001269703,0.0005516363,0.02252624,0.0001605513,0.0009085509,0.000009021022],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998059,0.001027668,0.000270013,0.00002960586,0.000008662254,0.000004240085,0.0002011527,0.00001106972,0.0003885579],"genre_scores_gemma":[0.9987238,0.0003527453,0.000349815,0.00004976728,0.0000104972,0.000005469472,0.0001830193,0.000005367798,0.0003195355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008745231,"threshold_uncertainty_score":0.002528548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03847872111329006,"score_gpt":0.3106661170853023,"score_spread":0.2721873959720123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}